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Immune system / Interleukin 17 / Interleukin 23 / Interleukin / Inflammatory bowel disease / Faecal calprotectin / Tumor necrosis factor-alpha / Biomarker / Colitis / Cytokines / Biology / Medicine


Biomarkers of Therapeutic Response in the IL-23 Pathway in Inflammatory Bowel Disease
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City

Piscataway / Carlsbad / Valdez P. / Candidate / Cary / Mountain View / Marseille / Santa Cruz / Rochester / Cruz / Minneapolis / Valencia / Birmingham / Palo Alto / Alto / La Jolla / Billerica / Foster City / Penzberg / /

Company

Millipore Corporation / GraphPad Software / Qiagen / GE Healthcare / Merck & Co. / Sina / Elson CO. / Dynabio SA. / monoclonal Ab / Merck Research Laboratories / The Jackson Laboratory / MedImmune / Creative Commons / Schering-Plough / /

Country

Netherlands / France / Germany / United States / /

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Event

FDA Phase / Product Issues / Natural Disaster / /

Facility

Bar Harbor / University of Alabama / Laboratory Animal Care / American College of Gastroenterology All / Mayo Clinic / /

IndustryTerm

treatment of inflammatory bowel disease / gene product / naı¨ve / statistical software / helpful tool / /

MedicalCondition

Tumour necrosis / gut inflammation / colon and inflammatory bowel disease / gastrointestinal disorder / T-cell-dependent colitis / chronic colitis / adenoma / cancer / ulcerative colitis / active disease / pancreatitis / colonic disease / inflammatory pathways / inflammatory responses / macrophage inflammatory protein / IBD / cell dissociation / malignant tumor / inflammatory bowel disease / T cell-mediated intestinal inflammation / intestinal inflammation / mucosal inflammation / complete disease / colon inflammation / colitis / CD40induced inflammation / autoimmune encephalomyelitis / Tumor necrosis factor-a / T-cell-dependent mouse colitis / intense colonic inflammation / Inflammatory Bowel Disease INTRODUCTION Inflammatory bowel disease / established colitis / disease / C3H/HeJ SCID / active Crohn’s disease / immune-mediated colitis / anti-CD40 induced colitis Rag2 / mice / Crohn’s disease / autoimmune colitis / Andersson J. The SCID / reverses active colitis / T cell-mediated colitis / human inflammatory bowel disease / SCID / inflammatory dendritic cells / inflammation / human disease / /

MedicalTreatment

Adoptive transfer / /

Organization

Association for Assessment / Division of Gastroenterology and Hepatology / Institutional Animal Care and Use Committee / Institutional Review Board of the Mayo Clinic / the American College / FDA / Genome-wide / University of Alabama at Birmingham / National Institute of Health / Therapeutic administration / Food and Drug Administration / Institutional Animal Care and Use Committee of Schering-Plough Biopharma / Association for Assessment and Accreditation of Laboratory Animal Care / /

Person

Smiley Chen / Charles O. Elson / Lorena Taricani / Jeanine Mattson / Brent S. McKenzie / Rene de Waal Malefyt / Dave Parry / Robert A. Kastelein / Hudson / Katia Boniface / Erin Murphy / Wendy M. Blumenschein / Maria-Christina Malinao / Edward P. Bowman / Brant SR / Barbara Joyce-Shaikh / Maribel Beaumont / Corinne Cayatte / Jeffrey Grein / Rick Cheung / Van Deventer / Felix Vega / Beth Basham / Daniel Cua / Robert H. Pierce / William A. Faubion / /

Position

Associate Principal Scientist / author / Major / representative / clinical coordinator / /

Product

IL-23 / IL-23R / penicillin / IL-23 Efficacy / IL-17A / balanced salt / IL-22 / TNF / mice / A9 / /

ProvinceOrState

Minnesota / Alabama / California / /

PublishedMedium

PLoS One / /

Technology

gene expression / genotype / gel electrophoresis / alpha / antibodies / Biotechnology / pdf / drug development / /

URL

http /

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