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American Thoracic Society Documents An Official ATS Statement: Hepatotoxicity of Antituberculosis Therapy Jussi J. Saukkonen, David L. Cohn, Robert M. Jasmer, Steven Schenker, John A. Jereb, Charles M. Nolan, Charles A.
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Document Date: 2013-05-02 13:01:57

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File Size: 1,26 MB

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City

San Francisco / Montreal / Philadelphia / Memphis / DILI / Seattle / Baltimore / Seoul / San Diego / /

Company

Western European / Individuals Limited / Amazon / Alteon Inc. / /

Continent

Africa / Asia / /

Country

Canada / Korea / India / Taiwan / Germany / Zambia / Haiti / United States / Spain / /

Currency

pence / /

EntertainmentAwardEvent

Jussi / /

Event

Product Recall / Product Issues / FDA Phase / /

Facility

Pharmacy Treatment / Pharmacy RECOMMENDATIONS REGARDING TB DILI Program Infrastructure Standardized / /

IndustryTerm

Chemical cofactors / Internet address / Treatment of LTBI and of TB Disease / foreign chemicals / carrier / brief search / treatment for HIV / Clear and recurring communications / chemicals / carrier population / Treatment of TB Disease / treatment of LTBI and TB disease / treatment for TB disease / Treatment of LTBI Treatment of TB Disease / /

MedicalCondition

Chronic ethanol abuse / acute viral hepatitis / muscle injury / unexplained fatigue / HIV / significant hepatitis / symptomatic hepatitis / liver disorder / Factors Malnutrition / alcohol abuse / rheumatoid arthritis / Persistent steatotic injury / cirrhosis / MDR TB / hepatitis B / nonzonal necrosis / certain dose-related injury / injury / severe liver injury / hepatitis / hypoglycemia / liver disease / renal dysfunction / hepatic disease / Such injury / malnutrition / Granulomatous hepatitis / abdominal pain / chronic ethanol use / vasculitis / Rare hepatocellular injury / brucellosis / Bland cholestasis / metabolic acidosis / chronic alcohol consumption / Nonalcoholic fatty liver disease / both hepatitis C / coincidentally developed hepatitis A / HCV / fever / latent TB infection / lethargy / Released tumor necrosis / hepatic injury / vomiting / HCV infection / fulminant liver failure / AIDS / TB Disease Conclusions Drug-induced liver injury / infection / chronic medical conditions / viral hepatitis / rash / cholestasis / hepatocellular injury / eosinophilia / acute injury / superimposed injury / severe hepatic disease / probable isoniazid hepatitis / TB / occult liver disease / significant liver injury / undiagnosed liver disease / chronic use / TB disease / replaced viral hepatitis / nausea / active hepatitis B / Drug-induced acute hepatitis / symptomatic liver injury / hepatitis C / alcoholic and nonviral liver diseases / hepatic dysfunction / Subacute hepatic necrosis / encephalopathy / obesity / lymphadenopathy / severe illness / severe liver disease / hypersensitivity / Extensive TB disease / primary biliary cirrhosis / hypoalbuminemia / alcoholism / nonprogressive injury / HIV infection / isoniazid-related hepatitis / tuberculous meningitis / Excretion Drug-induced Liver Injury / severe alcoholism / insulin resistance / hemolytic anemia / acute liver failure / Latent tuberculosis infection / simple fatty liver / isoniazid-induced liver injury / fatal liver injury / pyrazinamide-induced liver injury / disease / chronic liver disease / specific hepatitis / prior isoniazid hepatitis / idiopathic liver failure / hepatocyte necrosis / Severe hepatocellular injury / focal hepatic necrosis / GENERAL CONCEPTS Definition Drug-induced liver injury / Idiosyncratic hypersensitivity / hepatic failure / treatment-associated liver injury / DILI DURING TREATMENT OF LATENT TB INFECTION DILI / alcoholic hepatitis / probable and possible isoniazid hepatitis / ulike syndrome / DRUG-INDUCED LIVER INJURY / hepatitis B. In / liver injury / acute hepatocellular injury / occasionally eosinophilic hypersensitivity / alcohol withdrawal seizures / chronic hepatitis B / injuries / tuberculosis / /

MedicalTreatment

highly active antiretroviral therapy / organ transplants / HAART / Liver transplant / counseling / hemodialysis / /

NaturalFeature

Pacific Islands / /

Organization

U.S. Public Health Service / American Thoracic Society / ATS Board of Directors / Medication Administration / International Union Against Tuberculosis / National Academy of Clinical Biochemistry / Provider Education and Resources Pretreatment Clinical Evaluation Patient Education Medication Administration / Centers for Disease Control and Prevention / U.S. Food and Drug Administration / Hong Kong Chest Service / /

Person

David L. Cohn / Robert M. Jasmer / John Bernardo / John A. Jereb / Dorothy B. Strader / Charles M. Nolan / Charles A. Peloquin / David Nunes / Raman Venkataramanan / Concepts Definition / Timothy R. Sterling / Fred M. Gordin / Steven Schenker / /

Position

physician / General / pharmacist / Documents An Official / /

Product

acetaminophen / drugs / itraconazole / simvastatin / allopurinol / Pyrazinamide / phenytoin / prednisone / cipro / carbamazepine / sulfasalazine / Isoniazid / Rifampin / Resources Pretreatment Clinical Evaluation Patient Education Medication / ketoconazole / TB / 2E1 / /

ProvinceOrState

King County / Washington / California / Maryland / Illinois / Tennessee / Florida / North Carolina / Iowa / /

Region

Eastern Europe / /

Technology

genotyping / apoptosis / Drug Metabolism / /

URL

www.atsjournals.org / /

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