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Arene substitution patterns / Glucocorticoid / Organochlorides / ACE inhibitors drug design / Chemistry / 5-alpha reductase / IC50


Article pubs.acs.org/jmc Development of Potent and Selective Inhibitors of Aldo−Keto Reductase 1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase) Based on N-Phenyl-Aminobenzoates and Their Structure−Activity
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Document Date: 2012-03-19 10:59:01

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File Size: 2,33 MB

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City

Philadelphia / /

Company

Merck / COX / NO2 / Sorbent Technologies / /

Country

United States / /

Currency

pence / /

Event

Reorganization / /

Facility

University of Pennsylvania / University of Pennsylvania Mass Spectrometry Service Center / John Morgan Building / /

IndustryTerm

active site / software data system / chemical castration / oxyanion site / Chemical shifts / carboxyl / carboxylate / high resolution double-focusing electrospray ionization/chemical ionization spectrometer / resultant solution / yellow oil / /

Organization

University of Pennsylvania / University of Pennsylvania Mass Spectrometry Service Center on an Autospec / Perelman School of Medicine / FDA / the University of Pennsylvania / Department of Pharmacology / Center of Excellence / Department of Chemistry / /

Person

Michael C. Byrns / † Yi / Mo Chen / Barry M. Twenter / Rakesh Kohli / Jeffrey D. Winkler / Trevor M. Penning / /

Position

Fisher / representative / /

Product

COX-1 IC50 / AKR1C3 / dimethyl sulfoxide / /

ProvinceOrState

Pennsylvania / /

RadioStation

Bruker AM-500 / /

Technology

pharmacokinetics / gene amplification / X-ray / 3g / /

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