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Chemistry & Biology, Vol. 11, 1293–1299, September, 2004, 2004 Elsevier Ltd. All rights reserved. DOIj .c he m bi ol1 3 Identification of Novel Small-Molecule Inhibitors of Severe Acute Re
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Document Date: 2010-12-19 08:35:05

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Discussion Phenotype / Phenotype / Procedures Phenotype / New York / Wong / /

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Leica Microsystems / Bayer / Ling A.E. / ChemBridge Corporation / Hitachi / Wilson / Elsevier Ltd. / Barber S.A. / Accelrys / SPSS / Amersham Biosciences / /

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Switzerland / United States / /

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M&A / FDA Phase / /

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DNA duplex / Chemistry The University of Hong Kong Pokfulam / duplex DNA / Queen Mary Hospital / /

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active site / protein/chemical interactions / chemical-resistant viruses / chemical libraries / chemical genetics offers / free energy / chemical genetic platform / cleavage products / cell culture media / chemical genetic approaches / chemical library / putative autolytic cleavage site / proteolytic processing events / energy / empirical binding free energy function / treatment of herpes / genetic algorithm / proteolytic processing / cleavage site / digital imaging system / bank / functional groups / chemical genetics / Chemical genetics resulting / chemicals / /

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viral infection / Severe Acute Respiratory Syndrome / Herpes / tissue-culture infectious dose / herpes simplex disease / Significance Viral infection / full-length infectious cDNA / disease / SARS / SARS-CoV infection / severe acute respiratory syndrome-associated coronavirus / endemic atypical pneumonia / successful viral infection / viral infections / virus infection / diseases / AIDS / infection / herpes simplex virus / human disease / /

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World Health Organization / Infectious Disease Fund / University of Hong Kong Pokfulam / Research Fund for the Control of Infectious Diseases / HKU SARS Donation Fund / Department of Microbiology / Vice-Chancellor SARS Fund / Department of Biochemistry / Aaron Diamond AIDS Research Center / Queen Mary Hospital / /

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Nat / Virol / Huang / Robert Shapiro / Chen / Richard Y. Kao / Julian Davies / William Benter / Wayne H.W. Tsui / Huey / Jason Madar / /

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General / King / reporter / /

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Nix / SARS-CoV / VE607 / /

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S.K. / New York / South Dakota / /

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electrophoresis / high-throughput screening / Lamarckian genetic algorithm / digital imaging system / chemical libraries / rational drug design / gene expression / gel electrophoresis / 0.5 Lamarckian Genetic Algorithm / flash / drug development / be easily observed following polyacrylamide gel electrophoresis / /

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www.who.int/csr/sars/en / /

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