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Breast cancer / Tumor markers / Tumor suppressor genes / Mutation / BRCA1 / BRCA2 / Risk factors for breast cancer / Ovarian cancer / Breast Cancer Research and Treatment / Medicine / Biology / Oncology


Breast Cancer−Associated Abraxas Mutation Disrupts Nuclear Localization and DNA Damage Response Functions Szilvia Solyom, et al. Sci Transl Med 4, 122ra23 (2012); DOI: [removed]scitranslmed[removed]
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Document Date: 2012-03-19 10:59:02


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A. Ziogas S. A. / Hoya / Millipore / Savo / V. McGuire A. S. / Sequenom Inc. / Wilson / SPSS / Covance / S. S. / SignaGen Laboratories / Nikon / A. Smogorzewska S. P. / N. Tung A. E. / S. J. Ramus S. A. / Pearson / Boeing / Epicentre Technologies / P. D. Pharoah S. A. / Li-Cor Inc. / /

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University of Oulu / National Center / P. Hall / C terminus / University of Eastern Finland / Cancer Center of Eastern / Brca1 A complex / Oulu University Hospital / IR-induced G2-M checkpoint / Kuopio University Hospital / Memorial Sloan-Kettering Cancer Center / Abramson Family Cancer Research Institute / Tampere University Hospital / Abraxas complex / Broadway Research Building / McKusick-Nathans Institute of Genetic Medicine / National Cancer Institute / University Hospitals / Laboratory Medicine / G2 checkpoint / Institute of Clinical Medicine / University of Tampere / University of Pennsylvania / The BRCA1-RAP80 complex / Laboratory of Cancer Genetics / /

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online version / software version / software analysis / multimarker algorithm / protein products / sucrose containing solution / tumor suppressor network / splice-site / /

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ovarian cancer / IR hypersensitivity / diagnosis/metastasis / neuroblastoma / Finnish cancer / informative tumors / same breast cancer / BRCA-centered tumor / breast and breast - ovarian cancer / fibrosarcoma / prostate cancer / familial and unselected breast cancer / breast cancer / only mutation-positive breast cancer / lobular tumor / tumor / lung and lip cancer / negative breast cancer / R361Q-positive breast cancers / germline human breast cancer / Cancer / BRCAassociated breast cancer / tumors / ipsilateral primary breast tumors / R361Q-positive tumors / Tumor ER / upper aerodigestive tract cancers / J. Cancer / lobular disease / breast and endometrial cancer / sarcoma / Abraxas- or RAP80-deficient tumor / breast and ovarian cancer / invasive breast cancer / INTRODUCTION Breast cancer / studied breast cancer / positive breast cancer / familial cancer / deficiency / hereditary susceptibility / DNA Damage Response Functions Breast cancer / novel breast cancer / lymphoma / highly enriched tumor / early disease / ARTICLE BREAST CANCER Breast Cancer / Colon tubular adenoma / yet unexplained disease / Fanconi anemia J / WT familial breast cancer / upper aero80 digestive tract cancers / 22q12-q13 breast cancer / multiethnic breast cancer / cancers / C rare cancer / serous epithelial ovarian cancer / familial breast cancer / common cancer / primary disease / hereditary predisposition / lentigo maligna / disease / low-penetrance breast cancer / leiomyoma B02 Lobular ER / BRCA1 tumor / unselected breast cancer / familial cancers / reliable cancer / Finnish breast cancer / invasive lobular and ductal breast carcinoma / R361Q variant caused hypersensitivity / BRCA1 tumors / single ovarian cancer / inherited breast cancer / /

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radiation / chemotherapy / /

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Microsoft Windows / Dos / /

Organization

Laboratory of Cancer Genetics / Cancer Center / Genome-wide association / Kuopio University Hospital / University of Tampere / Department of Clinical Genetics / McKusick-Nathans Institute of Genetic Medicine / Finnish Red Cross Blood Service / Cancer Fund of Savo / Finnish Cancer Society / Institute of Clinical Medicine and Biocenter Oulu / Tampere University Hospital / University of Oulu / Finnish Red Cross / National Cancer Institute / Oulu University Hospital / Ida Montini Foundation / Sigrid Jusélius Foundation / University of Pennsylvania / Centre for Laboratory Medicine / Perelman School of Medicine / Pennsylvania School of Veterinary Medicine / Cancer Fund / Academy of Finland / Finnish Ministry of Social Affairs and Health / Cancer Susceptibility Club BRCA1 / National Center for Biotechnology Information / Johns Hopkins University School of Medicine / American Association for the Advancement of Science / Finnish Cancer Foundation / Institute of Clinical Medicine / Memorial Sloan-Kettering Cancer Center / Tyyni Tani Foundation / Center of Excellence / Abramson Family Cancer Research Institute / /

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D. Paik / Nat / Ov / S. Sangrajrang / V / A. Menezes / V / M. Kosma / V / H. Tuhkanen / V / A. Dunning / A. Mannermaa / V / Jeffrey Patterson / A. van den Ouweland / T. Truong / V / K. Offit / V / J. A. Stamatoyannopoulos / Bernadette Aressy / V. M. Kosma / V / M. Grip / V / A. Bucur / V / K. T. Kelsey / T. Walsh / W. Sieh / V / A. Fink-Retter / H. Eerola / V / S. H. Ahn / M. Uusitupa / V / L. A. Aaltonen / V / K. B. Meyer / C. Y. Shen / S. E. Hankinson / Santos Silva / Contribution / R. Tumino / V / I. Holcatova / V / B. van der Luijt / /

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SequiTherm EXEL II / iPLEX / Triton / G2 checkpoint signaling / tumor models / DNA damage response function / nuclear accumulation / /

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Maryland / South Dakota / Pennsylvania / Northern Savo / /

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Clinical Medicine / /

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Eastern Finland / Northern Finland / /

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radiation / genotyping / chemotherapy / genotype / recombination / gel electrophoresis / antibodies / Biotechnology / ATM / laser / DNA Sequencing / SNP / Tagger multimarker algorithm / simulation / /

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www.sciencetranslationalmedicine.org/cgi/content/full/4/122/122ra23/DC1 / http /

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