Ge / Proc Natl Acad Sci U S A / SRI International / R-BAC / Medline / Systat Software / Knudsen / GHB / /
Country
Japan / /
Currency
USD / / /
Event
Product Recall / M&A / Product Issues / Business Partnership / FDA Phase / /
Facility
Research Institute of Environmental Medicine / Nagoya University / Laboratory Animal Care / Washington State University / Yamanaka laboratory / Laboratory Animals / /
IndustryTerm
Experimental protocol / unknown binding site / factor drug / treatment for insomnia / energy homeostasis / food / Chronic dosing protocol / treatment of sleep disorders / factors drug / unpublished reagents/analytic tools / sodium oxybate oral solution / /
MedicalCondition
bi-daily chronic dosing study / drug addiction / juvenile onset narcolepsy / cataplexy and improved daytime sleepiness / cataplexy and increased sleep intensity / cataplexy data / cataplexy bout duration differences / chronic dosing period / baseline cataplexy density / chronic dosing study / behavioral state disorders / X syndrome / awake unchanged chronic dosing / Mody / obesity / TetO diphtheria toxin mice / cataplexy density / cataplexy bout duration / express diphtheria / human narcolepsy / cataplexy and cataplexy density / hypersomnolence / Chronic dosing protocol / insomnia / improved narcolepsy / delayed hypersomnolence / Chronic dosing / cataplexy and cataplexy bout duration / cataplexy density change / baseline cataplexy amounts / chronic dosing day / narcolepsy / cataplexy bouts / chronic dosing paradigm / Cataplexy S / chronic administration / cataplexy / excessive daytime sleepiness / chronic recording / sleep disorder canine narcolepsy / baseline cataplexy levels / early onset narcolepsy / TetO diphtheria / Hypocretin (orexin) deficiency / Reduces Cataplexy / Chronic dosing study Effects / cataplexy control / high cataplexy levels / sleep disorders / depression / cataplexy / cataplexy amounts / therapeutics Introduction Narcolepsy / /
MedicalTreatment
Surgery / drug therapy / /
NaturalFeature
McMaster MT / /
Organization
National Research Council / Nagoya University / Nagoya / Washington State University / Japan Science and Technology Agency / Department of Integrative Physiology and Neuroscience / R-BAC administration / Research Institute of Environmental Medicine / Center for Neuroscience / Association for Assessment and Accreditation of Laboratory Animal Care / Subchronic administration / /
Person
Ann Neurol / Jeremiah Palmerston / Daniel Valladao / Lars Dittrich / Van Cauter / Akihiro Yamanaka / Takeshi Sakurai / Thomas Kilduff / NREM EEG / /
The Journal of Neuroscience, May 7, 2014 • 34(19):6485– 6494 • 6485 Neurobiology of Disease GABAB Agonism Promotes Sleep and Reduces Cataplexy in Murine Narcolepsy