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Genomics / Metabolism / Systems biology / Pharmacology / Toxicity / Hepatotoxicity / Toxicogenomics / Metabolomics / Metabolic pathway / Toxicology / Biology / Medicine


ALTEX Online first published June 23, 2014 http://dx.doi.org[removed]altex[removed]Pathway-Based Toxicity: History, Current Approaches and Liver Fibrosis and Steatosis as
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Document Date: 2014-06-23 05:52:08

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File Size: 2,46 MB

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City

Newark / Bradford / TGF / Ispra / DILI / SREBP / Pathway / Baltimore / Brussels / /

Company

Unilever / Research Centre’s European Union Reference Laboratory / Proc Natl Acad Sci U S A / EMC / Bradbury S. P. / OECD Extended Advisory Group / Action Working Group / DuPont / CAAT / ExxonMobil Biomedical Sciences Inc. / /

Country

Italy / Belgium / United States / /

Currency

USD / pence / /

Event

FDA Phase / /

Facility

Joint Research Centre / Building Shared Experience / European Commission Joint Research Centre’s European Union Reference Laboratory / /

IndustryTerm

extrapolation tools / chemical categories / reference chemicals / http /

MedicalCondition

Neoplasms / granuloma formation / AOs liver fibrosis / Idiosyncratic liver injury / cirrhosis / inflammatory mediators / SEURAT fibrosis MoA / chronic inflammation / injury / acute and chronic exposure / hepatitis / liver disease / Chronic liver injury / cancer / repeated injury / non-alcoholic fatty liver disease / Allergic reactions / viral hepatitis / cholestasis / Hepatocellular injury / fibrosis / cellular necrosis / scar / continued injury / inflammatory cells / chronic injury / human breast cancer / liver steatosis / Mode-of-Action frameworks The IPCS cancer / acute liver failure / necrosis / disease / hepatocyte injury / liver injury Drug-induced liver injury / Liver Fibrosis / adenocarcinoma cells / bacterial infection / fatty liver / drug-induced liver injury / Liver injury / liver fibrosis Liver fibrosis / inflammation / human disease / /

Organization

Public Health Center for Alternatives / OECD AOP / National Research Council / US Environmental Protection Agency / Society of Environmental Toxicology and Chemistry / Institute for Health and Consumer Protection / IPCS MoA / Humane Society of the United States / Institute for Chemical Safety Sciences / European Commission / FDA / European Union / National Institute of Health / European Commission's Joint Research Centre / Mid-Continent Ecology Division / European Centre for Ecotoxicology and Toxicology of Chemicals / Safety & Environmental Assurance Centre / Organization for Economic Cooperation / Organization for Economic Cooperation and Develo / European Commission Joint Research Centre / Johns Hopkins School / Environmental Protection Agency / /

Person

Van Leeuwen / Brigitte Landesmann / Hy Zimmerman / Jessica Caverly Rae / Katy O. Goyak / Arch Toxicol / /

Position

engineer / COACH / COACH / the project coordination activity / scientist / Director / reporter / /

Product

glycine / Vitamin D / P-450 / 2.4 Drug / P450 / /

ProgrammingLanguage

EC / php / /

ProvinceOrState

Maryland / /

Technology

proteomics / apoptosis / DNA Chip / gene expression / metabolomics / alpha / Expert System / Toxicogenomics / drug metabolism / bioinformatics / hybridization / transcriptomics / UDP / pdf / DNA sequencing / CHIP-on-chip / drug development / /

URL

http /

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