| Document Date: 2009-03-09 15:09:13
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City La Jolla / / Company IBM / TRAF2 / AMP / IRE1 / Medtronic / / Country United States / / Currency ADP / / / Event Product Issues / Business Partnership / / Facility C terminus / DRP1 BI1 BCL-XL BAR / Burnham Institute / N terminus / / IndustryTerm juxtamembrane site / proteolytic product / medical devices / cell death machinery / machinery / chemical inhibitors / inflammatory cytokine processing / proteolytic processing / diverse / chemical screens / degradation machinery / chemical chaperones / / MedicalCondition Hereditary mutations / atazanavir Cancer / Several additional neurodegenerative diseases / insulin resistance XBP1 / Jakob disease / amiodarone Polyglutamine diseases / ‡For Huntington’s disease / reperfusion injury / viral infection / lymphoma / eIF2α pathway Salubrinal Parkinson’s disease / stroke GRP78 / brain injury / ASK1 Polyglutamine disease / Bipolar disease / B-cell leukaemia / rheumatoid arthritis / multiple myeloma cells / tissue injury / ASK1 deficiency / Heart disease / Huntington’s disease / Prion disease / amyotrophic lateral sclerosis / SMERs Polyglutamine diseases / leukaemia / Obesity / inclusion-body myositis / chronic therapies / inflammatory cytokine processing / human diseases / myeloid cell leukaemia sequence / polyglutamine diseases / rodent stroke / inflammatory diseases / tertbutylhydroquinone Stroke / hypotension / cells CHOP Cancer / PERK Autoimmune disease / middle cerebral artery occlusion / B-cell leukaemia/lymphoma / p38 MAPK antagonists Stroke / Alzheimer’s disease / chronic neurodegenerative diseases / protein-inclusion-body diseases / cancer / lateral sclerosis Inflammation / disease / Atherosclerosis / brain diseases / stroke / human neuroblastoma cell line / diabetes / stroke injury / lateral sclerosis / focal ischaemia stroke / oxidative injury / breflate Cancer / transmissible spongiform encephalopathies / §For spinocerebellar ataxia / seizure / Myocardial infarction / Parkinson’s disease / diseases / cardiac disease / infection / neurodegenerative diseases / inflammation / tumour necrosis factor / spinobulbar muscular atrophy / syndrome / bipolar disorder / disorders / / MedicalTreatment Immunosuppression / / OperatingSystem ISIS / / Organization Burnham Institute for Medical Research / US Food and Drug Administration / / Person Wenjie Xu / John C. Reed / C. Reed Abstract / / / Position mediator / additional candidate / rodent model of global brain ischaemia138 / known mediator / reporter / / Product nitro / PERK pathway / embryos / / ProvinceOrState California / / Technology siRNA / high-throughput screening / apoptosis / drug discovery / Prions / / URL www.nature.com/reviews/drugdisc / /
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f o c u S o n a pRoEpVto SIS IEW Cell death and endoplasmic reticulum stress: disease relevance