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ORIGINAL ARTICLE The Heritability of Bipolar Affective Disorder and the Genetic Relationship to Unipolar Depression Peter McGuffin, MB, PhD, FRCP, FRCPsych; Fruhling Rijsdijk, PhD; Martin Andrew, MB, MRCPsych; Pak Sham,
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Cardiff / London / /

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CE E ACE AE / Free AE / Wiley & Sons / Cardno AG / P Value AIC ACE AE / Oxford University Press / Farmer AE / /

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United Kingdom / /

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Virginia Commonwealth University / National Institute of Mental Health / University of Wales College / Virginia Institute / Arch Gen Psychiatry / Toronto University / Institute of Psychiatry / King’s College / ARCH GEN PSYCHIATRY/ VOL / Maudsley Hospital / New York State Psychiatric Institute / /

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manic syndrome / depressive disorders / manicdepressive illness / Bipolar (BPD) Affective Disorder / both disorders / both common factors affecting disorders / Shields J. Schizophrenia / manic-depressive disorders / psychotic disorders / only depression / psychotic illness / disorder / affective disorders / DSM-IV unipolar depression / affective illness / DSM-III-R disorders / moderately severe and mild affective disorders / Functional Psychoses / schizophrenia / both mania / unipolar depression / Proband Co-twin Monozygotic Dizygotic Monozygotic Dizygotic Depression Mania Depression Mania Depression Mania Mania Depression / DSM-IV affective disorder / mania / II disorders / manic-depressive disorder / psychiatric disorders / affective disorder / either mania / Bipolar Affective Disorder / Endogenous Psychoses / depression / disorders / bipolar disorder / /

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Denmark Hill / /

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Stanley Foundation / Department of Psychological Medicine / Maudsley Hospital / Virginia Commonwealth University / Department of Psychology / King’s College London / Medical Research Council / Toronto University / Toronto / Social / Genetic / and Developmental Psychiatry Centre / University of Wales College of Medicine / Institute of Psychiatry / Developmental Research Centre / Virginia Institute for Psychiatric and Behavioral Genetics / American Medical Association / Bethesda / Psychiatric Institute / Oxford University / National Institute of Mental Health / /

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Alison Macdonald / Drs Andrew / Fruhling Rijsdijk / William Heinemann / Lewis / Anne Farmer / Psychiatry Centre / Bina Coid / Piero Venturi / Ann Hum / Martin Andrew / Robin Murray / Irving Gottesman / Lisa Jones / Randy Katz / Nadia Davies / Peter McGuffin / Alastair Cardno / Jane Marshall / Tracy Ribchester / Joan Rutherford / Adrianne Reveley / /

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author / study Corresponding author / Fisher / Marshall / /

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London / Virginia / Ontario / /

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Reveley AM / Macdonald AM / /

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Genomics / /

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WWW.ARCHGENPSYCHIATRY.COM / http /

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