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Pharmacology / Medicinal chemistry / Proteins / Pharmacy / Signal transduction / Biological target / Drug discovery / Receptor antagonist / Acetylcholine / Pharmaceutical sciences / Chemistry / Biology


Identifying mechanism-of-action targets for drugs and probes Elisabet Gregori-Puigjanéa,1, Vincent Setolab,1, Jérôme Herta, Brenda A. Crewsc, John J. Irwina, Eugen Lounkined,
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Document Date: 2012-06-18 11:04:28


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City

Wood / San Francisco / Hopkins / Schramm / Cambridge / Nashville / Dewar / /

Company

ACS / DrugBank / Ligand / Castoreno AB / Pearson / COX / Drug Bank / excluding DrugBank / /

Currency

CYP / USD / /

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Facility

eNational Institute of Mental Health Psychoactive Drug Screening Program / The Pennsylvania State University / University of North Carolina / Chapel Hill / University Park / Chapel Hill School / University of California / /

IndustryTerm

high chemical similarity / ingenious chemical biology tool / chemical probes / chemical libraries / chemical biology approaches / pharmaceutical / basic local alignment search tool / chemical tools / chemical information approach / mining / chemical similarities / literature search / chemical / pharmaceutical aids / /

MedicalCondition

receptor Cough / disease / chronic myelogenous leukemia / cough / depression / /

Organization

University of California / National Institute of Health / Department of Pharmaceutical Chemistry / Chapel Hill School of Medicine / Food and Drug Administration / University of North Carolina / Division of Chemical Biology and Medicinal Chemistry / The Pennsylvania State University / Neuroscience and Lineberger Cancer Center / Vanderbilt University School of Medicine / eNational Institute of Mental Health Psychoactive Drug Screening Program / /

Person

Vincent Setolab / Elisabet Gregori-Puigjanéa / Lawrence Marnettc / Jérôme Herta / John J. Irwina / Comb Chem High / Brian K. Shoicheta / Eugen Lounkined / Brenda A. Crewsc / Mark Burlingame / Bryan L. Rothb / /

Position

MP / Author / /

Product

mesalamine / escitalopram / mercaptopurine / indomethacin / dapsone / anastrozole / antitussive / fluoxetine / sulfadiazine / glycine / azathioprine / SEA / /

ProvinceOrState

New Jersey / Alabama / Tennessee / New Foundland and Labrador / North Carolina / California / Massachusetts / /

Technology

Alpha / Neuroscience / chemical genomics / PKI / Drug Screening / pharmacokinetics / chemical libraries / drug discovery / chemoinformatics / pharmacodynamics / drug development / /

URL

www.pnas.org/cgi/doi/10.1073/pnas.1204524109 / www.pnas.org/lookup/suppl / /

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