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Lactones / Statins / Oncology / Lovastatin / Doxorubicin / Alcohols / HMG-CoA reductase / Chemotherapy / Daunorubicin / Medicine / Anthracyclines / Chemistry


Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity
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Document Date: 2011-08-11 06:00:37

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City

Hannover / Gilbertsville / Munich / Heidelberg / Chester / Cairo / Lo¨rrach / Santa Cruz / Merseyside / Dreieich / Du¨sseldorf / Mainz / Mannheim / Steinheim / Cambridge / Oberkochen / San Diego / /

Company

XPA / Thermo Fisher / Cell Signaling Technology Inc. / Roche Diagnostics / Millipore / SIGMA-Aldrich / Sigma-Aldrich Chemie GmbH / Qiagen / MERCK / GE Healthcare / Kremer LC / Life Diagnostics / Carl Zeiss AG / Becton Dickinson / Creative Commons / XPC / Macmillan Publishers Limited / /

Country

United Kingdom / Germany / United States / /

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Event

Business Partnership / /

Facility

Institute of Clinical Chemistry / Heinrich Heine University / University Medical Center / University Du¨sseldorf / Institute of Toxicology / Laboratory Medicine / Institute of Pathology / /

IndustryTerm

xeroderma pigmentosum complementation / cancer therapy / immediate early gene product / anthracycline-based tumortherapeutic protocols / antiapoptotic gene products / trichrome staining protocol / bp product / in vivo model systems / /

MedicalCondition

cardiac tissue injury / fibrosarcoma cells / JE / xeroderma pigmentosum complementation group A / human fibrosarcoma cells / human fibrosarcoma xenograft model / xeroderma pigmentosum complementation group C / cardiac dysfunction / squamous cell carcinomas / Fibrosarcoma / breast cancer / tumor / ventricular dysfunction / cardiomyopathy / Cancer / tumors / Carcinogenesis / human fibrosis / Anthracycline-induced clinical heart failure / doxorubicin-based cancer / chronic cardiac damage / fibrosis / cardiac fibrosis / metastasis / J Cancer / colon cancer / advanced/metastatic breast cancer / Doxorubicin-induced cardiac dysfunction / human sarcoma / congestive heart failure / Clinical heart failure / Disease / tumor necrosis / heart failure / malignant glioma cells / pediatric cancers / radiation-induced intestinal fibrosis / clearly reduced tumor growth / /

MedicalTreatment

radiotherapy / radiation / cancer therapy / statin therapy / anticancer therapy / chemotherapy / /

NaturalFeature

Piascik MT / /

Organization

University Medical Center of the Johannes Gutenberg University Mainz / Mainz / Germany and 4Institute of Toxicology / University Medical Center of the Johannes Gutenberg University Mainz / Institute of Clinical Chemistry and Laboratory Medicine / Institute of Toxicology / Institute of Pathology / /

Person

Alexa Fluor / Adriana Degreif / Heinrich Heine / Ann Oncol / Rebekka Kitzinger / Ban Y et al. Topoisomerase / Katrin Roth / Fritz G. Lovastatin / Fritz G. Targeting / /

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Position

RT / Multi Analyst / Cole MP / MyIQ Thermal Cycler / representative / real-time PCR cycler / *Corresponding author / Harper / Porter / Kaminski PM / Virag L et al / /

Product

acetylcysteine / Simvastatin / SIGMA / dexrazoxane / etoposide / penicillin / nitro / lovastatin / /

ProvinceOrState

South Dakota / /

PublishedMedium

PLoS One / /

RadioStation

Azarova AM / /

Technology

radiation / X-ray / apoptosis / anthracycline-based tumortherapeutic protocols / gene expression / chemotherapy / treating cancer / alpha / antibodies / ATM / DNA binding / trichrome staining protocol / /

URL

http /

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