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Anthracyclines / Doxorubicin / Dexrazoxane / Chemotherapy / Epirubicin / Acute myeloid leukemia / Streptomyces peucetius / Daunorubicin / Mitoxantrone / Medicine / Oncology / Chemistry


Topoisomerase 2β: A Promising Molecular Target for Primary Prevention of Anthracycline-Induced Cardiotoxicity
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Document Date: 2014-02-03 14:11:16

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City

Houston / Austin / Top2 / Cairo / /

Company

Eastern Cooperative Oncology Group / ADP / Henkel / Kremer L.C. / Lehman / Dana / Von Hoff D.D. / Provincial Systemic Treatment Disease Site Group / /

Country

United States / /

Currency

pence / /

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Event

FDA Phase / Product Issues / /

Facility

Cancer Prevention Research Institute of Texas / DNA complex / Luke’s Episcopal Hospital / anthracycline-Fe3+ complex / anthracycline-Fe2+ complex / Naunyn Schmiedebergs Arch / University of Texas MD Anderson Cancer Center / Fe complex / Liu’s laboratory / /

IndustryTerm

cancer therapy / treatment of neoplastic disease / imaging / treatment of cancer / Cancer Prevention / cancer treatment / energy production / Energy reserves / near-identical protocol / advance online publication / /

MedicalCondition

M.S. Congestive heart failure / anthracycline-induced cardiomyopathy / Myelodysplastic syndrome / finally cardiac dysfunction / doxorubicin-induced congestive heart failure / profound mitochondrial dysfunction / acute lymphoid leukemia / melanoma / childhood leukemia / poisoning / pediatric Hodgkin’s disease / papillary carcinoma / advanced breast cancer / breast cancer / art human cancer / leukemia / tumor / mitochondrial dysfunction / cancer / tumors / incremental injury / chronic animal models / J. Cancer / Telomere dysfunction / osteosarcoma / K.B. Doxorubicininduced mitochondrial dysfunction / lymphomas / childhood cancer / acute lymphoblastic leukemia / mitochondrial cardiomyopathies / anthracycline cardiomyopathy / chronic anthracycline cardiotoxicity / acute myeloid leukemia / amsacrine-resistant P388 leukemia / peripartum cardiomyopathy / doxorubicin-induced cardiomyopathy / chronic adriamycin administration / lymphoma / severe cardiac dysfunction / pediatric acute lymphoblastic leukemia / both acute and chronic animal models / M.M. Acute leukemia / metastatic breast cancer / neoplastic disease / Acute nonlymphocytic leukemia / doxorubicin-induced cardiac dysfunction / cardiac and pulmonary protection / papillary thyroid carcinoma / arrhythmia / second neoplasms / congestive heart failure / secondary acute myelogenous leukaemia / leftventricular dysfunction / chronic doxorubicin cardiotoxicity / W.E. Cardiac disease / Secondary acute myeloid leukemia / childhood Hodgkin’s disease / advanced non-small-cell carcinoma / heart failure / acute myeloid leukemia/ myelodysplastic syndrome / sarcomas / Hodgkin’s lymphoma / acute lymphoblastic leukaemia / acute myelogenous leukemia / Doxorubicin-induced mitochondrial dysfunction / acute myeloid leukemia/myelodysplastic syndrome / /

MedicalTreatment

radiotherapy / radiation / cancer therapy / salvage therapy / radiation therapy / combination chemotherapy / antibiotics / chemotherapy / /

Organization

American Society of Clinical Oncology / 2Texas Heart Institute/St. Luke’s Episcopal Hospital / University of Texas / National Institute of Health / American Society for Clinical Pharmacology and Therapeutics / Cancer Prevention Research Institute of Texas / R.A. Delayed administration / J. Lab. / US Food and Drug Administration / /

Person

Van Vleet / Nat / Hudson / Zina Deretsky / Franco / V / Schroeder / /

Position

mediator / molecular mediator / Carpenter / Fisher / Porter / /

Product

cisplatin / acetylcysteine / Dexrazoxane / Daunomycin / etoposide / prednisone / cyclophosphamide / fluorouracil / adenosine / mitoxantrone / Top2 / PGC1α/β SOD Thioredoxin Peroxiredoxin Cell death Illustrated / /

ProvinceOrState

Texas / /

PublishedMedium

Baseline / /

Technology

radiation / X-ray / apoptosis / magnetic resonance imaging / gene expression / chemotherapy / treating cancer / recombination / alpha / near-identical protocol / /

URL

www.nature.com/cpt / /

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