| Document Date: 2015-05-28 10:53:18
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IndustryTerm diffusion-weighted imaging / typical imaging findings / / MedicalCondition diffuse infiltrating glioma / tumor / measurable disease / adequate pre-trial FFPE tumor / mumps / disease / seizures / yellow fever / Seasonal influenza / high-grade glioma / dyspnea / active autoimmune disease / measles / rabies / glioma / uncontrolled seizures / active Hepatitis B / serious infections / non-brainstem high grade glioma / Hepatitis C / Hepatitis B / Eligibility Criteria Tumor / hypothyroidism stable / typhoid / Sjogren’s syndrome / noted infectious disease / Pulmonary / rubella / intranasal influenza / brainstem tumors / hypersensitivity / vitiligo / clinically significant unrelated systemic illness / organ dysfunction / autoimmune disease/syndrome / refractory high-grade gliomas / neurologic deficits / Exclusion Criteria Concurrent Illness / pneumonitis / varicella / significant interstitial lung disease / true progressive disease / refractory non-brainstem high-grade glioma / asthma / HCV RNA / / MedicalTreatment radiation therapy / birth control / anticancer therapy / immunosuppressive therapy / hormone replacement / vaccination / chemotherapy / radiotherapy / platelet transfusion / Bone Marrow Transplant / drug therapy / immunotherapy / Radiation / / Position investigator / chair / / Technology Pharmacokinetics / radiation / gene expression / chemotherapy / spectroscopy / MRI / /
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PBTC-045: A Safety and Preliminary Efficacy trial of MKpembrolizumab; anti-PD-1) in Children with recurrent, progressive or refractory high-grade gliomas (HGG) and DIPGs Abstract and Schema This is a two phase saf