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Cell biology / Genes / Hippo signaling pathway / Gene expression / RNA interference / NUMB / Mammalian target of rapamycin / Drosophila melanogaster / Arrestin / Biology / Cell signaling / Signal transduction


Reports mate of ~11.5% experimental false positive rate with SS ≥ 0.8. Of known biochemical interactions between Hippo pathway components, 16 out of 31 expected interactions (table S4) with the baits (~52% coverage)
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Document Date: 2013-10-10 14:54:45

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File Size: 3,27 MB

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City

Porto / Austin / Boston / Waltham / /

Company

M. E. Sowa S. P. / J. E. Elias S. P. / Medline / Target / Lamp1 / R. Rad S. A. / K. VijayRaghavan S. P. / /

Country

United States / /

Currency

pence / cent / /

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Facility

Howard Hughes Medical Institute / Brandeis University / Drosophila RNAi Screening Center / /

IndustryTerm

positive regulatory network / lysosomal maker / protein-protein interaction network / search strategy / protein complex network / genetic interaction networks / /

MedicalCondition

tumor / cancer / Hippo tumor / fold-change Warts / MS / Fat tumor / breast cancer / /

Organization

Brandeis University / Harvard Medical School / G. Halder / Drosophila RNAi Screening Center / Center for Complex Systems / Bloomington Stock Center / Genome-wide association / Department of Computer Science / Department of Cell Biology / DsHarvard Medical School / Damon Runyon Cancer Research Foundation / Modulating F-actin / Strong / Howard Hughes Medical Institute / Transgenic RNAi Project / Department of Genetics / /

Person

Norbert Perrimon / S. Blair / K. Irvine / R. L. Finley / Jr. / Nat / Steven P. Gygi / /

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Position

Investigator / HippoCorresponding author / Yki-reporter / reporter / /

Product

Tao / RNAi / /

ProvinceOrState

Massachusetts / /

PublishedMedium

Complex Systems / /

Technology

alpha / proteomics / functional genomics / Hpo / stem cells / apoptosis / /

URL

www.sciencemag.org/cgi/content/full/science.1243971/DC1 / http /

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