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Cell cycle / P53 / Aurora B kinase / Wee1 / Postreplication checkpoint / CHEK1 / Cyclin-dependent kinase 1 / Ataxia telangiectasia and Rad3 related / Carcinogenesis / Biology / Cell biology / Proteins


DNA replication stress in CHK1-depleted tumour cells triggers premature (S-phase) mitosis through inappropriate activation of Aurora kinase B
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Document Date: 2014-05-22 08:45:07

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File Size: 3,02 MB

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Beeston / Feltham / Houston / Oviedo / Sheffield / Baltimore / Liverpool / Oxford / Loughborough / Cambridge / London / Paisley / /

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VWR International / Checkpoint / IgG / Vector Laboratories / Nikon / Olympus / Sigma-Aldrich / Amersham / Becton Dickinson / Merck / Macmillan Publishers Limited / /

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United States / United Kingdom / /

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Product Issues / /

Facility

University of Sheffield / The University of Sheffield / University of Liverpool / Checkpoint Kinase / MRE11-NBS1-RAD50 complex / Johns Hopkins University / Cdk1 complex / Institute of Integrative Biology / /

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autophosphorylation site / cancer therapy / /

MedicalCondition

colorectal cancer / neuroblastoma / colon cancer / SW480 human colon cancer / another p53 defective colon cancer / p53-deficient colon cancer / Nucleotide deficiency / ataxia-telangiectasia / cancer / Disease / tumour / chronic transcriptional alterations / Grupo Espan˜ol de Investigacio´n en Sarcomas / tumours / /

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cancer therapy / /

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School of Medicine and Biomedical Sciences / Medical School / Johns Hopkins University / University of Liverpool / Instituto de Salud / Instituto Universitario / University of Sheffield / Department of Biochemistry / Department of Oncology / Institute of Integrative Biology / Molecular Oncology Unit / /

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Aurora B. Furthermore / Alexa Fluor / Gene Dev / Aurora Kinase / Bert Vogelstein / /

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Spain *Corresponding author / mediator / RT / Hwang PM / Representative / /

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H3 / PUMA / colon cancer cell line SW480 / tumour cells / /

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J / /

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Southend-on-Sea / South Dakota / /

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radiation / siRNA / antibodies / Biotechnology / ATM / Cell Signaling / stem cells / apoptosis / DNA synthesis / treating cancer / condensation / recombination / /

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http /

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