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Cell cycle / Transcription factors / Tumor suppressor genes / DNA replication / P53 / Ataxia telangiectasia mutated / P21 / H2AFX / Cell cycle checkpoint / Biology / Cell biology / Proteins


Vol 444 | 30 November 2006 | doi:nature05268 LETTERS Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
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Document Date: 2011-06-08 05:03:13


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Geneva / Sheffield / Stockholm / Ioannina / Philadelphia / Athens / Copenhagen / Santa Cruz / /

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Checkpoint / Becton Dickinson / Linke S. P. / /

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Switzerland / Sweden / United States / United Kingdom / Greece / Denmark / /

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Facility

University of Sheffield / Aarhus University Hospital / University Hospital / University of Geneva / University of Athens / DNA DSB checkpoint / National Cancer Institute / Institute of Cancer Biology / University of Ioannina / Wistar Institute / University of Pennsylvania / Stockholm University / /

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online version / /

MedicalCondition

colon adenomas / jb@cancer / lymphoma development / non-small-cell lung carcinomas / nonsmall cell lung carcinoma / benign mouse skin papillomas / premalignant tumours / larger and more invasive tumours / carcinoma / same colon adenoma / serum starvation / tumor / adenomas / Cancer / NSCLC / human cancer / mouse skin carcinogenesis / tumour / DNA double-strand break response kinase ataxia telangiectasia / SCID / infection / carcinomas / both adenomas / tumours / /

Organization

National Cancer Institute / Stockholm University / Danish National Research Foundation / University of Geneva / 2The Wistar Institute / University Hospital / Swiss National Foundation / Demokritos National Center for Scientific Research / Danish Cancer Society / Relief Foundation / Institute of Cancer Biology / School of Medicine / Department of Medicine / University of Sheffield / Greek General Secretariat of Technology PENED / GR11635 Athens / European Commission / National Hellenic Research Foundation / University of Pennsylvania / Philadelphia / 11The Institute for Cancer Studies / Swedish Cancer Society / 8Gastroenterology Division / University of Athens / Aarhus University Hospital / University of Ioannina / /

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ACA AAC AGG UGA UAU / Chen / /

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D. J. / Author Information Reprints / T.D. / experienced pathologist / Mouse model for senescence as tumorigenesis barrier / Representative / /

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F-16 / /

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Pennsylvania / /

PublishedMedium

Molecular Biology / /

Technology

electrophoresis / siRNA / antibodies / Biotechnology / ATM / apoptosis / ATG / recombination / gel electrophoresis / performed using optimally titrated antibodies / /

URL

www.nature.com/nature / www.nature.com/reprints / /

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