| Document Date: 2010-12-01 14:33:58
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City Rapamune / Sirolimus / Reference / / Company Wyeth Pharmaceuticals Inc. / / Event Product Recall / Product Issues / / IndustryTerm food / / MedicalCondition established hyperlipidemia / lymphoma/lymphoproliferative disease / Lymphoma / headache / Hypersensitivity Reactions Hypersensitivity / urinary tract infection / hypersensitivity vasculitis / Skin Cancer / nausea / thrombocytopenia / diarrhea / Hypersensitivity / hepatic artery thrombosis / sepsis / lymphedema / pleural effusion / nephrosis / fatal infections / Hemolytic Uremic Syndrome/Thrombotic Thrombocytopenic Purpura / Proteinuria / abdominal pain / hypertension / opportunistic infections / arthralgia / hypertriglyceridemia / Carcinogenesis / Hyperlipidemia / fever / rhabdomyolysis / pain / Latent Viral Infections / Angioedema / lymphoma and other malignancies / infection / angioedema / exfoliative dermatitis / lymphocele / pericardial effusions / anemia / hypercholesterolemia / Interstitial Lung Disease / tuberculosis / / MedicalTreatment Renal Transplantation / renal transplants / liver transplant / Vaccination / organ transplants / lung transplant / IMMUNOSUPPRESSION / immunosuppressive therapy / organ transplant / dialysis / renal transplant / / Organization DOSAGE AND ADMINISTRATION / FDA / / / Position physician / / Product Cyclosporine / Rapamune / acute rejection / amphotericin B / CsA / Prednisone / azathioprine / Rapamune Following Cyclosporine / prescribed amount of Rapamune Oral Solution / Use Cyclosporine / / Technology drug metabolism / antibodies / transplantation / Pharmacokinetics / Pharmacodynamics / dialysis / / URL www.fda.gov/medwatch / /
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Patients at low- to moderate-immunologic risk • Rapamune and Cyclosporine Combination Therapy: One loading dose of 6 mg on day 1, followed by daily maintenance doses of 2 mg (2.1). • Rapamune Following Cyclosporine