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Tumor markers / Tumor suppressor genes / PARP inhibitor / PARP1 / Cellular processes / Aging / Olaparib / RAD51 / Homologous recombination / Biology / Medicine / DNA repair


SEE COMMENTARY Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition Przemek M. Krawczyka,1, Berina Eppinkb,1, Jeroen Es
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Document Date: 2012-03-08 04:41:28


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City

buffalo / Rotterdam / Amsterdam / /

Company

Bethyl Laboratories / Apogee / APL / Adobe Systems / Millipore / Sigma-Aldrich / Astra / AstraZeneca / /

Country

Netherlands / /

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Event

FDA Phase / Product Issues / /

Facility

Erasmus Medical Center / Rad51 complex / The Rockefeller University / Scale bar / University of Amsterdam / Bethel JA / Academic Medical Center / The Mre11 complex / /

IndustryTerm

cancer therapy / cancer therapies / reagents/analytic tools / cancer treatment / noninvasive tool / mammalian genome surveillance machinery / chemical agents / /

MedicalCondition

rat rhabdomyosarcoma / human colon cancer / rhabdomyosarcoma model / fresh tumor / significantly influence tumor / primary human melanoma / vivo tumor / implanted tumors / BRCA2-mutated cancers / J Cancer / cervix carcinoma / human melanoma / bulk tumors / animal tumor / human squamous lung carcinoma / BRO-derived human melanoma / MS / localised high-risk soft-tissue sarcoma / breast cancer / leukemia / tumor / squamous cell carcinoma / cancer / tumors / HR-proficient tumor / advanced solid tumors / BRCA2-deficient tumours / such an effective tumor / osteosarcoma / unrelated rat tumor / HR-deficient tumors / BRO melanoma tumor / hind limbs bearing tumors / Targeted cancer / rhabdomyosarcoma tumor / C. The tumors / hereditary BRCA2-deficient tumors / excessive tumor / irradiated tumor / heat shock / rhabdomyosarcoma tumors / rhabdomyosarcoma / /

MedicalTreatment

adjuvant chemotherapy / radiotherapy / immunotherapy / anti-cancer therapies / Radiation / cancer therapy / cancer therapies / Vascular Surgery / /

MusicGroup

N.A.P. / /

Organization

Dutch Cancer Society / Erasmus Medical Center / Van Leeuwenhoek Centre for Advanced Microscopy / Department of Radiotherapy / Organization for Scientific Research / Center for Experimental / Rockefeller University / New York / University of Amsterdam / Cancer Genomics Center / Academic Medical Center / Department of Cell Biology and Histology / Spatial / Center for Experimental and Molecular Medicine / /

Person

Lukas J. Stalpersf / Alex Zelenskyb / Hans Rodermonde / Berina Eppinkb / Przemek M. Krawczyka / Thomas Soulliéh / Nicolaas A. P. Frankene / Roland Kanaarb / Alexis Biochemicals / Jan Stapa / Gene Targeting Ef / Jacob A. Atena / Chris van Breee / /

Position

Farmer / Recombination mediator / representative for three independent experiments / Author / representative / /

Product

cisplatin / penicillin / Sigma / mitomycin / Polaroid a300 Digital Camera / homologous recombination / HER-2 / mutant cell lines / /

ProvinceOrState

New York / California / Arizona / /

Technology

Genomics / Radiation / 3-D / antibodies / siRNA / Cloning / DNA binding / laser / chemotherapy / treating cancer / gene targeting / recombination / down-regulated using siRNA / /

URL

www.pnas.org/cgi/doi/10.1073/pnas.1101053108 / www.pnas.org/lookup/suppl/doi / /

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