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Apoptosis / Bcl-2 / BH3 interacting-domain death agonist / Fas receptor / Annexin / Bcl-xL / BCL2L2 / Melanoma / Dacarbazine / Biology / Cell biology / Programmed cell death


Sensitization to the mitochondrial pathway of apoptosis augments melanoma tumor cell responses to conventional chemotherapeutic regimens
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Document Date: 2012-11-15 05:59:31

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City

Gilbertsville / Minneapolis / Valencia / New York / Fremont / Darmstadt / Santa Cruz / /

Company

Vector Laboratories / Chipuk Laboratory / D M SO C AB / Millipore / T73 7 0 C AB / Qiagen / C VD AB / EL BIM-L BIM-S C VD AB / Fridolin Charitable Trust / Abbott Laboratories / Macmillan Publishers Limited / /

Country

Germany / United States / /

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Facility

Chipuk Laboratory / Case Western Reserve University / Tisch Cancer Institute / /

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IndustryTerm

live cell imaging / melanoma model systems / gross imaging / cancer treatment / irregular mitochondrial network / imaging / red free media / mitochondrial network / /

MedicalCondition

subcutaneous melanotic tumors / detectable tumor / Representative tumors / JE / metastasis / primary A375 melanoma tumors / equivalent tumor / murine B16 melanoma / melanoma / A375 tumor / Experimental Medicine Melanoma / reduced tumor / vivo melanoma / CVD-treated tumors / melanoma tumor / leukemia / A375 mCherry tumors / tumor / M SO tumor / significant tumor / cancer / tumors / Disease / cutaneous melanocytic neoplasms / A375 tumors / DMSO GAPDH A375 mCherry CAM tumors A375 / malignant melanoma / B-RAFV600E positive melanoma / pulmonary melanoma metastases / E. The A375 tumor / B-cell lymphoma / primary tumor / metastatic melanoma / /

MedicalTreatment

antibiotics / chemotherapy / combination chemotherapies / adjuvant therapy / /

Organization

National Institute of Health / PI (red) / Mount Sinai School of Medicine Department of Oncological Sciences One Gustave L. Levy Place / Case Western Reserve University / 3The Tisch Cancer Institute / JJR Foundation / Mount Sinai School of Medicine Department of Oncological Sciences / Spivak Fund / /

Person

Mark Lebwohl / Emily Bernstein / Gustave L. Levy / Simona Podgrabinska / Gotham Narla / Stuart Aaronson / /

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Position

interacting mediator / *Corresponding author / Representative / /

Product

T73 7 % Annexin V 125 / cisplatin / BH3 / B-RAFV600E / acetic acid / DV / dacarbazine / /

ProvinceOrState

New Brunswick / New York / South Dakota / /

Technology

Antibodies / siRNA / digital camera / apoptosis / chemotherapy / condensation / gel electrophoresis / CVD / /

URL

www.nature.com/cddis / /

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