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Apoptosis / Proteins / Bcl-2 / Bcl-xL / BH3 interacting-domain death agonist / MCL1 / BCL2L2 / Caspase / B-cell lymphoma / Biology / Cell biology / Programmed cell death


Citation: Cell Death and Disease[removed], e366; doi:[removed]cddis[removed] & 2012 Macmillan Publishers Limited All rights reserved[removed]www.nature.com/cddis Bcl-2 is a better ABT-737 target than Bcl-xL or Bcl-w
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Document Date: 2012-08-09 06:02:05


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Anaheim / Bubendorf / Oltersdorf / Berlin / Mannheim / Phoenix / Amsterdam / Diegem / Mountain View / Lincoln / San Jose / St. Louis / /

Company

Armstrong SA / Sigma-Aldrich / Werner AB / Letai A. / Billen LP / Creative Commons / GE Healthcare / BD Biosciences / Simmons / Shimizu / Alsop AE / Bio-Rad / Abbott Laboratories / Macmillan Publishers Limited / /

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Germany / Switzerland / Netherlands / Montserrat / Belgium / United States / /

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Event

FDA Phase / /

Facility

The Netherlands Cancer Institute / IMAGE library / The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital / /

IndustryTerm

cancer therapeutics / chemical library / mM stock solution / model systems / stock solutions / /

MedicalCondition

solid tumours / prototype cancer / small cell lung carcinoma / JE / lymphoma / Chronic lymphocytic leukemia / solid tumors / thrombocytopenia / wild-type and mutant leukemias / melanoma / small-cell lung cancer / SCLC / mantle-cell lymphoma / leukemias / MS / Leukemia / tumor / Cancer / tumors / Disease / diffuse large B-cell lymphoma / human T-acute lymphoblastic leukemia / malignant disease / lymphomas / lymphoma cells / Bcl-xL deficiency / chronic myeloid leukemia / leukemia/lymphoma / acute myeloid leukemia / T-ALL / J16 (Jurkat) T-ALL / /

MedicalTreatment

antibiotics / anticancer therapy / Radiotherapy / combined modality therapies / cancer therapeutics / /

Organization

Dutch Cancer Society / Division of Immunology / The Netherlands Cancer Institute / Organization for Scientific Research / /

Person

Frank van Diepen / Anita Pfauth / Huib Ovaa / Grant S. Mcl / Gaizo Moore V / Grant S. Bim / Madelon Paauwe / Van Delft / Ann Appl Biol / Wang X. Mule / Roelof Pruntel / /

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Position

*Corresponding author / mediator / Author / representative / /

Product

Sigma / doxycycline / etoposide / Puma / ABT-737 / Bcl-2 / /

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South Dakota / /

RadioStation

Keuling AM / /

Technology

X-ray / antibodies / cloning / apoptosis / pharmacokinetics / pharmacodynamics / /

URL

http /

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