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Apoptosis / Proteins / Immune system / Genes / Apoptosome / Bcl-2 family / Bcl-2 / Fas receptor / Rotenone / Biology / Cell biology / Programmed cell death


Mitochondrial inhibitor sensitizes non-small-cell lung carcinoma cells to TRAIL-induced apoptosis by reactive oxygen species and Bcl-XL/p53-mediated amplification mechanisms
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City

Jena / Nanjing / /

Company

IgG / Macmillan Publishers Limited / /

Country

Germany / China / /

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Event

FDA Phase / /

Facility

μg TRAIL / Nanjing University / Military Medical University / College of Life Sciences / China Pharmaceutical University / Affiliated Hospital / Second Military Medical University / Changhai Hospital / /

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IndustryTerm

cancer therapy / chemical molecules / /

MedicalCondition

non-smallcell lung carcinoma / NCI-H441 xenografts tumor / non-small-cell lung carcinoma / A549 tumor / xenografts tumor / tumor / mitochondrial dysfunction / cancer / tumors / Disease / NSCLC / well-known tumor / TRAIL-based cancer / respiration injury / Tumor necrosis / Lung cancer / especially highly malignant tumors / stressful tumor / TRAIL-resistant tumor / /

MedicalTreatment

anticancer therapy / cancer therapy / drug targeting / /

Organization

Military Medical University / Shanghai / 3The State Key Lab of Natural Medicines / State Key Lab of Pharmaceutical Biotechnology / Affiliated Hospital of the Second Military Medical University / Shanghai / College of Life Sciences / Changhai Hospital / Anesthesiology and Intensive Care Unit / China Pharmaceutical University / Nanjing / Nanjing University / Nanjing / Affiliated Hospital of the Second / /

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Position

China *Corresponding author / representative / /

Product

cisplatin / acetylcysteine / etoposide / A549 / /

Technology

siRNA / Biotechnology / apoptosis / treating cancer / /

URL

www.nature.com/cddis / /

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