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Small interfering RNA / Stable nucleic acid lipid particle / RNA interference / RNA transfection / Interferon / Toll-like receptor / Bio-Synthesis / Inc. / Pattern recognition receptor / Immune system / Biology / Genetics / RNA


Overcoming the Innate Immune Response to Small Interfering RNA
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Document Date: 2015-03-05 19:45:03

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IFN / Burnaby / /

Company

IgG / Thomson / Ge / COX / Diebold / Mary Ann Liebert Inc. / /

Country

Guinea / Canada / /

Event

Reorganization / FDA Phase / /

Facility

Bridge et al. / /

IndustryTerm

chemical toxicities / disease site / cancer therapy / machinery / preclinical immunization protocols / Chemical modification / chemical modification strategies / chemical modification approach / chemical modification strategy / chemical composition / antisense technology / allergy applications / design-based solution / active product / active targeting technologies / lipid delivery technologies / otherwise inert carrier / certain in vitro culture systems / chemical modifications / /

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inflammatory response / inflammatory reactions / inflammatory reaction / Ebola virus infection / viral infection / autoimmune disease systemic lupus erythematosus / previously published influenza / HBV / nonspecific tumor / severe shocklike syndrome / macular degeneration / inflammatory syndromes / thrombocytopenia / severe acute respiratory syndrome / immediate hypersensitivity / hepatitis B / inflammatory mediators / melanoma / inflammatory cytokines / lymphopenia / inflammatory cascade / clinical syndrome / hypotension / predominantly inflammatory cytokine response / tumor / systemic inflammatory response / cancer / disease / characteristic inflammatory reaction / inflammatory cytokine production / transient lymphopenia / inflammatory response syndrome / chills / influenza A / fever / allergy / pain / tumor necrosis / tumor necrosis factor / numerous virus infection / rigors / infectious diseases / parainfluenza / infection / eye disease / inflammation / herpes simplex virus / /

MedicalTreatment

immunization / premedication / cancer therapy / /

Person

Chiu / Morrissey / Rana / /

Position

representative / Small Interfering RNA ADAM JUDGE / JUDGE / /

Product

polyethylene glycol / siRNAbased / adenosine / CD28 / /

ProvinceOrState

British Columbia / /

Technology

ADAM / active targeting technologies / antisense technology / antibodies / siRNA / antisense molecules / lipid delivery technologies / GENE THERAPY / pharmacokinetics / preclinical immunization protocols / gene expression / treating cancer / drug development / /

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