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Signal transduction / Protein domains / Protein kinases / Genes / Piperazines / Abl gene / Tyrosine kinase / Imatinib / Tyrosine-kinase inhibitor / Biology / Medicine / Cell biology


BBRC Biochemical and Biophysical Research Communications–717 www.elsevier.com/locate/ybbrc Breakthroughs and Views
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Document Date: 2006-02-26 12:23:05

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City

Baltimore / Philadelphia / New Orleans / /

Company

Ciba-Geigy Pharmaceuticals / Novartis / ADP / Ó 2003 Elsevier Inc. / /

Continent

Europe / /

Country

United States / /

Currency

pence / /

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Event

FDA Phase / /

Facility

Bcr-Abl complex / /

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IndustryTerm

active site / chemical precursor / pharmaceutical industry / chemical inducer / normal and altered abl gene products / active-site / nucleotide-binding site / leukemia virus oncogene product / treatment of Philadelphia chromosome positive chronic myeloid leukemia / chimeric gene products / xeroderma pigmentosum gene products / protein substrate-binding site / gene product / treatment of cancer / oncoprotein product / catalytic site / sarcoma virus oncogene product / treatment of these cancers / treatment of AIDS / chemical / treatment of chronic myeloid leukemia / /

MedicalCondition

ataxia telangiectasia / blast phase / blast crisis / advanced gastrointestinal stromal tumors / gastrointestinal stromal tumors / Xeroderma / chronic myelogenous leukaemia / leukaemia virus protein / Xeroderma pigmentosum / chronic phase / disorder / hypersensitivity / chronic myelogenous leukaemia identified / Rous sarcoma / Bcr-Abl proteintyrosine kinase Chronic myeloid leukemia / malignant hematological disease / cancers / Leukemia / tumor / murine Abelson leukemia virus / gastrointestinal stromal tumor / chromosome-positive leukemias / cancer / Abelson leukemia / disease / rapidly fatal blast crisis / K562 leukemia / chronic myelogenous leukemia-like syndrome / cellular Abelson leukemia / human cancer / Rous sarcoma virus / positive chronic myeloid leukemia / acute lymphoblastic leukemia / chronic myelocytic leukaemia / inherited disease / lung cancer / several human cancers / diseases / blast phases / chronic myelogenous leukemia / T-cell leukemia / AIDS / xeroderma pigmentosum gene products / chronic myeloid leukemia / human chronic granulocytic leukemia / B-cell lymphoma / human disease / disorders / /

MedicalTreatment

molecular therapeutics / radiation / /

Organization

Robert Roskoski Jr.* Department of Biochemistry and Molecular Biology / Louisiana State University Health Sciences Center / United States Food and Drug Administration / American Cancer Society / /

Person

Brian Druker / Ray Erikson / B.M. Sefton / Nat / Edmond Fischer / How / M. Talpaz / Giulio Superti-Furga / A. Van Etten / Edwin Krebs / Bartholomew Sefton / M. Janicek / Rudolph Virchow / Janet Rowley / H. Kantarjian / Peter Nowell / R. Roskoski Jr. / S. Sudarsanam / Tony Hunter / D. Van den Abbeele / Oncogenic / S.W. Cowan-Jacob / V / John Kuriyan / L.F. Ten Eyck / V / David Hungerford / Robert Roskoski Jr. / /

Position

pathologist / model for all protein kinases / Singer / D.J. / /

Product

hydroxyurea / Gleevec / STI-571 / adenosine / Tyr412 / /

ProvinceOrState

Louisiana / /

PublishedMedium

Molecular Biology / /

Technology

radiation / X-ray / high-throughput screening / ATM / cell signaling / transplantation / human genome / apoptosis / drug design / gel electrophoresis / /

URL

www.elsevier.com/locate/ybbrc / /

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