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Bioorganic & Medicinal Chemistry Letters–41 Anthranilate 4H-oxazol-5-ones: novel small molecule antibacterial acyl carrier protein synthase (AcpS) inhibitors Adam M. Gilbert,a,* Matthew Kirisits,a Patrick
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Document Date: 2006-02-15 03:37:31


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City

Princeton / Umea / San Leandro / Cambridge / Washington DC / Chirgadze / Meriden / /

Company

Fischl A. S. / Elsevier Ltd. / Umetrics AB / Millennium Pharmaceuticals Inc. / Wyeth / /

Country

United States / Sweden / /

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Event

FDA Phase / /

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IndustryTerm

active site / uorescence resonance energy transfer / holo-acyl carrier protein / phosphopantetheinyl / molecule antibacterial acyl carrier protein synthase / acyl carrier protein synthase / pharmaceutical agents / vigorous search / apo-acyl carrier protein / /

MedicalCondition

MS / /

MedicalTreatment

antibiotics / drug therapies / /

Organization

American Chemical Society / National Committee for Clinical Laboratory Standards.12 / National Committee for Clinical Laboratory Standards / Department of Chemical / Pearl River Discovery Analytical Chemistry Pharmaceutical Pro / /

Person

Christian C. Fritze / Elena Novikova / Matthew Kirisits / Diane Joseph-McCarthy / Peter J. Petersen / Adam M. Gilbert / Iain McFadyend / /

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Position

Corresponding author / /

Product

penicillin / R2 / Glycine / R1 / M7-A / /

ProvinceOrState

New Jersey / Copeland / New York / Massachusetts / /

Technology

Molecular modeling / /

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