View Document Preview and Link Document Date: 2015-01-30 22:49:06 Open Document File Size: 1,40 MB Share Result on Facebook
City Cambridge / / Company Macmillan Publishers Limited. / Amgen / Celgene / MannKind Corporation / IgG / Johnson & Johnson / AstraZeneca / Burke Bioventures LLC / / Country United States / / Currency USD / / / Event FDA Phase / / Facility University of California / Koch Institute / Lupron Depot / Massachusetts Institute of Technology / / IndustryTerm drug solution / treatment of hepatitis C / situ-forming depot systems / licensed biological product / polymer solution / treatment of ovarian cancer / portable devices / pharmaceutical industry / drug product / cancer therapy / fusion-based products / millilitre protein solutions / depot formulation technologies / large pharmaceutical companies1 / injectable biopharmaceutical drugs / injectable depot technology / chemical conjugation / downstream processing / delivery systems / bio pharmaceutical drugs / formulation difficult as solutions / protein solutions / Chemical modification / food / manufacturing process / chemical definition / pharmaceuticals / biopharmaceutical drugs* / preclinical tools / chemical-based formulation strategies108 / analytical technologies / biopharmaceutical products / oil‑in‑water emulsion / biopharmaceutical drug delivery / Reverse thermal gelling systems / biopharmaceutical drug formulation / acceptable products / particle technologies / biopharmaceutical drug / immune systems / clinical applications / biopharmaceutical drugs / treatment of metastatic colorectal cancer / injection site / biotechnology / particulate systems / albumin-fusion products / biopharmaceutical polymer / delivery technology / oil phase / delivery technologies / bulky device / manufacturing complexities / biopharmaceutical delivery / chemical functionalities / treatment of certain types of oesophageal cancer / compact device / treatment of patients with breast cancer / injectable solutions / degradation products / microsphere-based controlled-release technologies / closed-loop device / vaccine applications / marketed biotechnology products / formulation technologies / combination product / biopharmaceutical modification / electronics / / MedicalCondition pulmonary route / ovarian cancer / pulmonary delivery / acromegaly / sterility / rheumatoid arthritis / inactivated polio virus / bone marrow metastases / chronic lifelong use / Pulmonary / Desmopressin Pulmonary / accidental injuries / psoriasis / prostate cancer / breast cancer / neutropenia / diabetes / HCV / antigen-expressing tumours / diseases / Infection / tumours / oral and pulmonary delivery routes / haemophilia / REVIEWS Kd The dissociation / hepatitis C / lung metastases / influenza / alcoholism / oesophageal cancer / pituitary dwarfism / tumour / metastatic colorectal cancer / bulky and expensive Pulmonary / T cell cancer / pain / growth hormone deficiency / needle phobia / severe haemophilia B / infectious diseases / / MedicalTreatment incision / immunosuppressive therapies / immunotherapy / cancer therapy / incisions / insulin pump / chemotherapy / catheter / dendrimers / / Organization University of California / Santa Barbara / Massachusetts Institute of Technology / Center for Bioengineering / European Union / Koch Institute for Integrative Cancer Research / Department of Chemical Engineering / US Food and Drug Administration / Transdermal administration / / Product Aranesp / Lupron Depot / Risperdal / glucagon / Depot injections / Doxil / Liver Monocyte Macrophage Figure 2 / paclitaxel / Zoladex / polyethylene glycol / Abraxane / risperidone / leuprolide acetate / Enbrel / Jet injections / insulin / for / S1 / drug / NCT01658501 / Discovery / NCT01774851 / IX60 / NCT01098539 / / ProvinceOrState California / Massachusetts / / RadioStation Core / / Technology genetic engineering / injectable depot technology / microsphere-based controlled-release technologies / delivery technologies / drug delivery / biopharmaceuticals / DRUG DISCOVERY / chemotherapy / treating cancer / antibodies / biotechnology / depot formulation technologies / polymerization / directed mutagenesis / ultrasound / The delivery technology / pharmacokinetics / phage display / electroporation / formulation technologies / particle technologies / / URL www.nature.com/reviews/drugdisc / / SocialTag 
REVIEWS Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies Samir Mitragotri1, Paul A. Burke2 and Robert Langer3