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City Hannover / Wistar / / Company Bayer Pharma AG / Bayer / dM D S A / Creative Commons / / Country Germany / / / IndustryTerm biological systems / inhaled metal oxides / chemical reaction / e.g. metal ion binding / advance computational tools / physical and chemical properties / / MedicalCondition chronic adversity / pulmonary microenvironment / inflammatory processes / pulmonary environment / overload-related inflammation / inflammatory milieu / pulmonary barrier disruption / chronic inhalation / pulmonary phospholipidosis / chronic retained cumulative dose-related effects / surfactant dysfunction / pulmonary system / persistent inflammation / pulmonary inflammation / pulmonary toxicity / pulmonary retained volumetric particle dose / inflammatory cells / integrated pulmonary effect / chronic occupational exposure regimen / cumulative pulmonary dose / chronic adversities / associative pulmonary particokinetics / overload-dependent pulmonary toxicity / / MedicalTreatment insufflation / / Organization National Park Service / Hannover Medical School / OECD / / / Position important critical qualifier / / Product BAL / pseudo / / Technology Drug Discovery / thermodynamics / simulation / / URL http / SocialTag 
Derivation of occupational exposure levels (OELs) of Low-toxicity isometric biopersistent particles: how can the kinetic lung overload paradigm be used for improved inhalation toxicity study design and OEL-derivation?