| Document Date: 2012-02-06 15:52:56
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Company BP / PET / / Event FDA Phase / / IndustryTerm therapy for recurrent/ progressive/ refractory disease / perfusion/diffusion imaging / perfusion imaging / imaging / / MedicalCondition spinal cord disease / refractory disease / tumor / especially malignant glioma / ependymoma and low grade glioma / Ependymomas / progressive medulloblastoma / anaplastic astrocytoma / pineoblastoma / anaplastic oligodendroglioma / progressive ependymoma / sustained disease / Diffuse/Intrinsic Brain Stem Gliomas / tumors / disease / sustained tumor / low grade glioma / Uncontrolled systemic hypertension / high-grade glioma / cardiac failure / glioblastoma multiforme / glioma Stratum C / metastasis / visual pathway tumors / ependymoma / same tumor / gliosarcoma types / stroke / gliomatosis cerebri / serious infections / Refractory Malignant Gliomas / cerebral PNET / pulmonary disease / high grade glioma / recurrent malignant glioma / intrinsic brain-stem glioma / unstable angina / myocardial infarction / malignant glioma / clinically significant peripheral vascular disease / diffuse brain stem glioma / spinal cord tumors / central non-cerebellar PNET’s / Medulloblastomas / anaplastic ganglioglioma / medulloblastoma / recurrent low grade glioma / bi-dimensionally measurable disease / brain stem glioma / clinically significant unrelated systemic illness / organ dysfunction / recurrent solid tumors / recurrent high-grade glioma / myocarditis / progressive low grade glioma / measureable tumor / brain tumor / diffuse intrinsic brainstem glioma / brain tumors / primary tumor / / MedicalTreatment chemo / radiation therapy / birth control / chemotherapy / radiotherapy / drug therapy / / Position major mediator / study chair / / Product dexamethasone / Camptosar / bevacizumab / / ProvinceOrState South Dakota / / Technology pharmacokinetics / radiation / 25/2012 Protocol / tomography / chemotherapy / MRI / /
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PBTC-022 v 15.0 Version Date: [removed]Protocol Abstract and Schema Phase II study of Bevacizumab plus Irinotecan (Camptosar™) in Children with Recurrent,