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City Gatch / Madras / / Company Simonovich S. P. / Merck / Matsuda / Amgen / King L. C. / American Chemical Society Communication (9) Simonovich S. P. / Wolchenhauer S. A. / Guram A. S. / MacMillan / ASSOCIATED CONTENT / Allen A. E. / / Country United States / Monaco / / / Event FDA Phase / / Facility Princeton University / / IndustryTerm αamino carbonyl product / high-profile pharmaceutical agents / morpholine / α-cyclic amino product / bromide catalysis protocol / observable product / amine coupling protocol / medicinal chemistry applications / prominent pharmaceutical agents / desired α-amination product / desired amination products / electron-rich aromatic systems / α-oxy-amino products / α-amination protocol / amination product / / Organization David W. C. MacMillan* Merck Center for Catalysis / Princeton University / / Person Wei Li / Ryan W. Evans / Van Humbeck / Jason R. Zbieg / Zambetti / / Position rt / Butler / AUTHOR INFORMATION Corresponding Author dmacmill@princeton.edu Notes The authors / G. P. / / Product Plavix / sodium iodide / CuBr2 / / ProvinceOrState New Jersey / M. B. / / Technology α-amination protocol / bromide catalysis protocol / http / ATM / amine coupling protocol / / URL pubs.acs.org / / SocialTag 
Communication pubs.acs.org/JACS Simple Catalytic Mechanism for the Direct Coupling of α‑Carbonyls with Functionalized Amines: A One-Step Synthesis of Plavix Ryan W. Evans, Jason R. Zbieg, Shaolin Zhu, Wei Li, and Davi