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City York / Boston / New York / TNF / / Company Eli Lilly / Matsuda / Lilly / Proc Natl Acad Sci U S A / Furukawa / Taisho Pharm / Syndexa Pharmaceutical Corporation / Merck / HP / Eli Lilly Pharmaceutical Company / / / Event Product Issues / / Facility Weir GC / Terminal Kinase Pathways / / IndustryTerm immune systems / pathogen-sensing systems / metabolic and immune systems / pathogen-sensing device / therapy for diabetes / energy / energy fluxes / response systems / Diabetes Care / / MedicalCondition inflammatory response / obesity-induced inflammation / DF / inflammatory and metabolic responses / fatty liver disease / JE / inflammatory origin / severe insulin resistance / Local and systemic insulin resistance / islet cell inflammation / rheumatoid arthritis / inflammatory cytokine / diet-induced insulin resistance / inflammatory cascades / inflammatory cytokines regulating insulin action / hepatitis C / metabolic and inflammatory responses / several other inflammatory mediators / inflammatory mediators / inflammatory and metabolic pathways / inflammatory gene expression profiles / INFLAMMATORY CYTOKINES / Chronic inflammation / Obesity / cellular insulin resistance / obesity-linked insulin resistance / hepatitis / obesity-related insulin resistance / I diabetes / inflammatory activity / cell dysfunction / insulin resistance / single inflammatory mediator / disease / metabolic diseases / atherosclerosis / systemic inflammatory cytokine levels / human obesity / obesity-induced insulin resistance / hyperglycemia / inflammatory response pathways / Complex Diseases / classic inflammation / dyslipidemia / additional inflammatory mediators / chronic inflammatory diseases / ER stress insulin resistance / frank diabetes / peripheral insulin resistance / diabetes / prolonged inflammatory response / inflammatory component / metabolic syndrome / inflammatory signaling pathways / tumor necrosis / inflammatory cascade leading / tumor necrosis factor / Diabetes Mellitus / AND INSULIN ACTION Inflammation / systemic inflammation / JNK2 deficiency / associated diseases / infection / inflammatory kinases / chronic metabolic diseases / inflammatory pathways / deficiency / metabolic disease / Inflammation / systemic insulin resistance / inflammatory responses / inflammatory / injuries / chronic inflammatory states / morbid obesity / / Organization Czech MP / Internal Revenue Service / Harvard School of Public Health / American Diabetes Association / Sandler Foundation / / Person S. Hotamisligil / Van Obberghen / / Position Yao PM / author / Ridker PM / Reilly MP / Cao / single inflammatory mediator / Fisher / / Product Samsung S73 Digital Camera / insulin production / insulin receptor signaling / / ProvinceOrState Newfoundland / Pennsylvania / Massachusetts / / Technology alpha / Cloning / apoptosis / gene expression / / SocialTag 
Role of Endoplasmic Reticulum Stress and c-Jun NH2-Terminal Kinase Pathways in Inflammation and Origin of Obesity and Diabetes Go¨khan S. Hotamisligil Metabolic and immune systems are the most fundamental