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Cytokines / Chemotaxis / Perception / Natural killer cell / Immune system / Interleukin / Chemokine / Cell migration / CXCR3 / Biology / Immunology / Cell biology


Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal Jason S. Parka,b,c, Benjamin Rhaua,b, Aynur Hermanna,b, Krista A. McNallya,b, Carmen Zhoua,b, Delquin Gongb
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Document Date: 2014-12-24 04:44:24


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File Size: 1,03 MB

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City

San Francisco / Houston / Baltimore / /

Company

Hubbell / CellASIC/ EMD Biosciences / ACEA Biosciences / J.S.P. / Cell Propulsion Laboratory / Rosenberg SA / CellASIC Corporation / /

Currency

pence / /

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Event

Business Partnership / FDA Phase / /

Facility

fHoward Hughes Medical Institute / dCardiovascular Research Institute / M. D. Anderson Cancer Center / Preclinical Therapeutics Core Facility / Cell Propulsion Laboratory / depot of CNO / University of North Carolina Medical School / Chapel Hill / Stable Di / cGladstone Institute of Cardiovascular Disease / University of California / /

IndustryTerm

generalizable genetic tools / microfluidic device / therapeutic cellular devices / oil-in-water emulsion method / biology advancing clinical applications / given site / orthogonal chemical signals / generalizable tool / Treatment of patients with metastatic melanoma / imaging / microfluidic chemotaxis assay device / optogenetic tools / consistent chemical gradient environment / bioluminescent imaging / treatment of a growing array of diseases / lymphocyte imaging / biotechnological and therapeutic applications / orthogonal tool / drug delivery systems / generalizable genetic tool / therapy for cancer / therapeutic applications / therapy for stroke / /

MedicalCondition

DF / JE / colorectal cancer / sequential tumor / J Cancer / human colorectal tumors / severe spinal cord injury / chronic wounds / symptomatic ischemic heart failure / MS / pancreatic cancer / NOD/SCID / tumor / different tumor / cancer / tumors / disease / human cancer / stroke / early metastasis / human colorectal carcinoma / diseases / increased tumor / cutaneous melanoma / infection / CNS injury / inflammation / Hodgkin tumor / metastatic melanoma / /

MedicalTreatment

adoptive transfer / Chemotherapy / Adoptive immunotherapy / immunotherapy / drug delivery systems / gene therapy / Mesenchymal stem cell therapy / cell therapy / /

NaturalFeature

Lotze MT / Stephan MT / /

Organization

National Institute of Health / NIH Nanomedicine Development Center / University of North Carolina Medical School / UCSF Institutional Animal Care and Use Committee / California Institute for Regenerative Medicine / Center for Synthetic Signaling and Motility Systems Engineering / The Johns Hopkins University School of Medicine / dCardiovascular Research Institute / Department of Biochemistry / National Institutes of Health Nanomedicine Development Center / Department of Cellular and Molecular Pharmacology / FDA / National Science Foundation Synthetic Biology Engineering Research Center / cGladstone Institute of Cardiovascular Disease / Medicine and fHoward Hughes Medical Institute / University of California / San Francisco / bThe Cell Propulsion Lab / Howard Hughes Medical Institute / /

Person

Byron Hann / Donghui Wang / Bryan Roth / Jason S. Parka / Katja Kolar / Ryan Liang / Brian Rabinovich / James Onuffera / Gq / Peter N. Devreotes / Hansi Liu / Carmen Zhoua / Cathy Liu / Don Hom / Krista A. McNallya / Bruce R. Conklina / Paul Phojanakong / Jackie Tam / Eric Wong / Wendell A. Lima / Benjamin Rhaua / /

Position

Sailor / forward in the development / Author / forward / one step back / designer / potent mediator / Major / Lutolf MP / /

Product

T-cell injection / cyclophosphamide / P-97 / Deliv Rev 65 / clozapine / B6 / Microsphere injection / CNO / /

ProvinceOrState

Maryland / California / /

RadioStation

Mhashilkar AM / /

Technology

Protein engineering / cell therapy / cloning / transplantation / stem cells / Discussion The technology / gene therapy / drug delivery / biomaterials / tissue engineering / artificial intelligence / Chemotherapy / Regenerative Medicine / /

URL

www.pnas.org/cgi/doi/10.1073/pnas.1402087111 / www.pnas.org/lookup/suppl/doi / /

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