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Company Comparator Canagliflozin Canagliflozin Group / Janssen Pharmaceuticals Inc. / / Event FDA Phase / Product Issues / / Facility Laboratory Tests Increases / Poison Control Center / / IndustryTerm renal tubular transport systems / monitor for hypoglycemia / food / energy / biguanide combination product / thyroid products / aqueous media / Monitor for signs and symptoms / / MedicalCondition Polyuria / Genital Mycotic Infections / postural dizziness / Vulvovaginal candidiasis / mycotic infection / hyperinsulinemia / headache / acidosis / female genital mycotic infections / recurrent infections / Hypersensitivity Reactions Hypersensitivity / clinically significant vitamin B12 deficiency / urinary tract infection / If acidosis / nausea / vulvovaginal mycotic infection / Metformin Hypoglycemia / syncope / candidal balanitis / fatigue / diabetic ketoacidosis / prerenal azotemia / obesity / male genital mycotic infections / renal disease / diarrhea / Hypersensitivity / Urinary tract infections / Vulvovaginitis / chronic metabolic acidosis / renal dysfunction / Hypoglycemia / pruritus / phimosis / Kidney infection / Vaginal infection / resistant bradyarrhythmias / neurologic manifestations / sepsis / Hypotension / acute myocardial infarction / mycotic infections / Hyperkalemia / Abdominal pain / megaloblastic anemia / acute congestive heart failure / Vitamin B12 deficiency / indigestion / Cystitis / diffuse rash / both intrinsic renal disease / shock / Carcinogenesis / Metabolic acidosis / hyperglycemia / Symptomatic hypotension / serious disease / hypothermia / ESRD / contraction / chronic / stable dose / Genital infection / congestive heart failure requiring pharmacologic management / diabetes / Vulvitis / significant renal insufficiency / biochemical hypoglycemia / erythema / metabolic acidosis lacking evidence / septicemia / serious hypersensitivity / seizure / orthostatic hypotension / vomiting / Lactic acidosis / sunburn / diabetes mellitus / urticaria / hyperchloremic metabolic acidosis / angioedema / pancreatitis / Lactic Acidosis Lactic acidosis / Thirst# Constipation / Balanitis / Severe hypoglycemia / rash / severe acidosis / anemia / acute renal failure / respiratory distress / poorly controlled diabetes / dehydration / pituitary insufficiency / / MedicalTreatment oral contraceptives / peritoneal dialysis / intravenous infusion / hemodialysis / alternative therapies / dialysis / circumcision / / Organization Poison Control Center / Excretion Canagliflozin Following administration / DOSAGE AND ADMINISTRATION / FDA / / / Product Pioglitazone / Topiramate / ranitidine / trimethoprim / Glimepiride / zonisamide / cimetidine / isoniazid / acetazolamide / rifampin / phenytoin / talc / Digoxin / metformin hydrochloride / canagliflozin / Hepatic Function / / Technology tomography / UDP / Geriatrics / Pharmacokinetics / Pharmacodynamics / dialysis / / URL www.fda.gov/medwatch / / SocialTag 
INVOKAMET™ (canagliflozin and metformin hydrochloride) tablets for oral use[removed]