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Cytokines / Immune system / Tumor necrosis factors / Apoptosis / Ewing sarcoma / Tumor necrosis factor-alpha / Biology / Medicine / Cell biology


Abstract #3565 Birinapant (TL32711), a Small Molecule Smac Mimetic, Induces Regressions in Childhood Acute Lymphoblastic Leukemia (ALL) Xenografts that Express TNF and Synergizes with TNF in Vitro – A Report from the
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Document Date: 2012-12-10 15:15:19

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City

Lubbock / Columbus / Malvern / /

Company

4TetraLogic Pharmaceuticals / TetraLogic Pharmaceuticals / Affymetrix / /

Country

Australia / /

Facility

Tech University Health Sciences Center / National Cancer Institute / Children's Hospital / University of New South Wales / BIRINAPANT IN VITRO ACTIVITY IS POTENTIATED BY TNF OR TRAIL / Cancer Institute Australia / /

MedicalCondition

Childhood Acute Lymphoblastic Leukemia / cancer / rhabdoid tumor / adult cancer / solid tumor / birinapant causes tumor / PPTP solid tumor xenografts / neuroblastoma cell lines / sarcoma / PPTP solid tumor / childhood ALL / SCID / rhabdomyosarcoma cell lines / selected rhabdomyosarcoma / /

MedicalTreatment

chemotherapies / /

Organization

National Cancer Institute / 3Texas Tech University Health Sciences Center / University of New South Wales / Sydney / 5Nationwide Children's Hospital / PPTP ALL / 2Children's Cancer Institute Australia / /

Person

Min Kang / Peter J. Houghton / Richard B. Lock / Brian Geier / Srinivas Chunduru / C. Patrick Reynolds / Bethesda / Malcolm A. Smith / Martin A. Graham / /

ProvinceOrState

Texas / Pennsylvania / New South Wales / /

Region

South Wales / /

Technology

gene expression / apoptosis / /

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