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City Gammaretrovirus / Laport / Rapoport / / Company Eaton / Elsevier Inc. / / / Facility Laboratory Medicine / University of Pennsylvania / / IndustryTerm cell processing / technologies / immune systems / disruptive technology / patient-specific product / pharmaceutical industry / altered processing escapemechanisms / automated cell culture systems / cell culture systems / cell culture media / lower manufacturing cost / leukapheresis network / tumor site / CAR-based strategies / cell products / model systems / culture systems / mainstream technology / manufacturing / altered peptide processing / large scale manufacturing / adoptive transfer technology / in vitro expansion protocols / / MedicalCondition inflammatory reaction / chemotherapy resistant leukemias / lymphoma / common tumor / solid tumors / anaphylaxis / colitis / melanoma / animal tumor / herpes simplex virus thymidine kinase / human carcinoma / tumor / cancer / tumors / disease / autologous GVHD syndrome / human cancer / contraction / hematologic malignancies / Fever / chronic infection / off tumor / rash / tumor infiltrating lymphocytes / not faithfully recapitulating human cancer / / MedicalTreatment chemo / immunization / adoptive transfer / leukapheresis / chemotherapy / radiotherapy / adoptive immunotherapy / immunotherapy / gene therapy / immunosuppression / cell therapy / / OperatingSystem Paulos / / Organization National Institute of Health / Perelman School of Medicine / Synthetic Biology Michael Kalos and Carl H. June Abramson Cancer Center / University of Pennsylvania / Philadelphia / Department of Pathology and Laboratory Medicine / / Person June Page / Carl H. June Abramson / / Position forward / the development / important evolutionary driver / engineer / Author / Fisher / / ProvinceOrState Pennsylvania / / Technology genetic engineering / cell receptors / cell therapy / antibodies / mainstream technology / CRISPR/Cas9 based-technologies / cell signaling / cloning / transplantation / in vitro expansion protocols / stem cells / apoptosis / PDF / gene therapy / recent CAR-based technologies / electroporation / previously evaluated using CAR technology / adoptive transfer technology / chemotherapy / disruptive technology / / SocialTag 
NIH Public Access Author Manuscript Immunity. Author manuscript; available in PMC 2014 July 25. NIH-PA Author Manuscript