Douglas D. D. / F. and Pereira S. P. / A. J. and Sirica A. E. / Coleman / Khan S. A. / Ahrendt S. A. / J. L. and Sirica A. E. / Ligand / IHCC / J. S. and Pereira S. P. / Creative Commons / Suzuki / /
Continent
Asia / /
Country
Egypt / Thailand / Australia / United Kingdom / Italy / United States / /
Currency
pence / / /
Event
Product Issues / FDA Phase / /
Facility
Imperial College / Hammersmith Hospital / St Mary’s Hospital Campus / /
IndustryTerm
self-expanding metal / magnetic resonance imaging / therapeutic devices / imaging / stent technology / removable fully-covered metal stent / /
MedicalCondition
human intrahepatic cholangiocarcinoma / hepatobiliary and pancreatic cancers / primary sclerosing cholangitis / HBV / resected tumours / larger tumours / Mechanisms DMM Cholangiocarcinoma / cysts / arteritis / inflammatory milieu / Cryptosporidiosis / human cholangiocarcinoma cell growth / inflammatory mediators / another chronic inflammatory biliary disease / chronic inflammation / Clinical terms Adenocarcinomas / liver-specific deficiency / clinical problem Epidemiology Cholangiocarcinoma / Liver cirrhosis / isolated cholangiocarcinoma / extrahepatic cholangiocarcinoma / human tumours / epithelial ovarian cancer / intrahepatic biliary cysts / chronic biliary inflammation / cholangiocarcinoma progression / invasive gastrointestinal adenocarcinoma / perihilar cholangiocarcinoma / inflammatory diseases / inflammatory and non-inflammatory mechanisms / lymph node metastases / tumor / biliary tract cancer / Chronic bile duct injury / advanced epithelial ovarian cancers / cancer / vasculitis / resultant chronic cholangitis / hepatocellular carcinoma / carcinogenesis / J. Cancer / tubular adenocarcinoma TK Human cholangiocarcinoma / diabetes / moderate pancreatitis / HCV / fever / biliary tract cancers / ulcerative colitis / HCV infection / Fulminant cryptosporidiosis / virus infection / inflammatory conditions / metastatic gallbladder carcinoma / diseases / pancreatitis / Several different infections / biliary diseases / infection / common primary liver cancer / B virus infection / progressive and early disease / common inflammatory mediator / human cholangiocarcinoma / cholestasis / Chronic intraductal gallstones / fibrosis / tumours / chronic carriers / gastric cancer / benign inflammatory condition / primary liver cancer / fatal cancer / strain / inflammatory prostaglandins / metastasis / Intrahepatic cholangiocarcinoma / Shahid A. Khan1 Cholangiocarcinoma / hepatitis C / colitis / colon cancer / cholangiocarcinoma cells / cholangiocarcinoma growth / inflammatory cytokines / obesity / sporadic cholangiocarcinoma / MS / primary biliary cirrhosis / cholangiocarcinoma / specific inflammatory mediators / sepsis / cancers / several cancers / disease / benign inflammatory fibrosing disease / Caroli’s syndrome / Schistosomiasis japonica / chronic liver disease / cholangiocarcinoma invasiveness / tumour / biliary sepsis / typhoid / tumor necrosis / hilar cholangiocarcinoma / Liver cancer / human cholangiocarcinoma growth / gallbladder carcinoma / bile duct cancer / biliary papillomatosis / inflammation / human disease / /
Centre for Pharmacology and Therapeutics / Department of Medicine / Hammersmith Hospital / Imperial College London / Division of Diabetes Endocrinology and Metabolism / /
Disease Models & Mechanisms 6, [removed]doi:[removed]dmm[removed]CLINICAL PUZZLE The challenge of cholangiocarcinoma: dissecting the molecular mechanisms of an insidious cancer