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City PANG / Bechara / Meyer / Atlanta / ELMS / / Company References BROWN L.A.S. / D.M. AND BROWN L.A.S. / NOBLE N.A. / New England Journal / GM / BROWN L.A.S. / / Country United States / / Facility Atlanta VA Medical Center / / IndustryTerm chronic damaging chemical imbalance / conventional treatment / proteom ic tools / chemical imbalance / blood products / evolv ing tools / / MedicalCondition pneumococcal sepsis / pulmonary glutathione homeostasis / Klebsiella pneumoniae bacteremia / prior chronic alcohol ingestion / alveolar epithelial barrier dysfunction / Acute Lung Injury Alcohol abuse / M.A. The acute respiratory distress syndrome / endotoxemia / alcohol-mediated liver disease / alcohol abuse / dysfunction / severe sepsis / tissue injury / small inflammatory nodules / cirrhosis / newer clinical and experimental evidence link ing alcohol abuse / inflammatory mediators / chronic alcohol ingestion / renal fibrosis / endotoxin-mediated acute edematous lung injury / Pulmonary / injury / gastrointestinal hemorrhage / critical illness / septic shock / experimen tal diabetes / severe infections / acute acute risk lung injury injury lung sepsis / R.T. Alcohol abuse / illness / Liver Disease / large / then alcohol abuse / apparent disease / both pneumonia / acute inflammatory stresses / chronic alcohol abuse / mitochondrial dysfunction / both acute lung injury / pneumonia / respiratory failure / bacterial pneumonia / Alveolar epithelial dysfunction / fatal injuries / traumatic injury / complex diseases / Chronic / less lung injury / respiratory dysfunction / Diabetes / oxidative injury / acute endotoxemia / cellular dysfunction / Acute Lung Injury ARDS / pneumococcal bacteremia / portal hypertension / alcoholic lung disorder / lung injury / diseases / lung infection / infection / alveolar macrophage dysfunction / pulmonary host response / pulmonary tissue / alco holic liver disease / consequent cellular dysfunction / acute injury / chronic ethanol feeding / lung dysfunction / epithelial barrier dysfunction / leukopenia / chronic damaging chemical imbalance / PUTTING SYSTEMS BIOLOGY APPROACHES INTO PRACTICE ALCOHOLIC LUNG DISEASE Corey D. Kershaw / pul monary fibrosis / chronic alcoholics / alveolar inflammation / severe lung injury / murine pulmonary tuberculosis / sarcoidosis / pulmonary host defenses / increases experimental tuberculosis / chronic alcohol / D. Alcoholism / Lung Disease / bac teremic Klebsiella pneumoniae pneumonia / complex lung diseases / interest Alcohol abuse / diverse pulmonary diseases / nonpulmonary organ dysfunction / community-acquired pneumonia / organ dysfunction / severe pneumonia / infections / alcoholism / sepsis / acute lung injury / less severe lung injury / PUTTING SYSTEMS BIOLOGY APPROACHES INTO PRACTICE Alcohol Abuse / Pneumocystis carinii infection / bacteremia / disease / alcoholic liver disease / hospital-acquired pneumonia / Mycobacterium tuberculosis / acute respiratory distress syndrome / noncardiogenic pulmonary edema / chronic ethanol ingestion / pulmonary glutathione deficiency / lthough alcohol abuse / Health PUTTING SYSTEMS BIOLOGY APPROACHES INTO PRACTICE infections / D.M. Chronic / tumor necrosis / lung cancer / severe deficiency / heart failure / glutathione deficiency / bacterial infection / human pul monary fibrosis / Infectious Diseases / alcohol-mediated oxidative injury / frequent and severe pneumonias / Pneumonia Alcohol abuse / liver injury / Blunted cough / cough / inflammation / Respiratory Disease / E.L. Chronic alcohol abuse / syndrome / tuberculosis / / MedicalTreatment immunosuppression / antibiotics / chemotherapy / Mechanical ventilation / / Organization Atlanta VA Medical Center / American Thoracic Society / US Federal Reserve / American Society of Nephrology / Emory University School of Medicine / Biology Center / American Medical Association / Bank of England / Division of Pulmonary / Allergy / and Critical Care Medicine / / Person Bernard / Hudson / David M. Guidot / Fernandez-Checa / Morris / COREY D. KERSHAW / / Position mediator / professor of Medicine / critical mediator / Marshall / / Product acetylcysteine / / ProvinceOrState New Brunswick / Alabama / ARDS / Rhode Island / South Carolina / Georgia / New Jersey / / PublishedMedium The Journal of Infectious Diseases / Journal of Clinical Investigation / Archives of Internal Medicine / Clinical Science / Infection and Immunity / New England Journal of Medicine / American Journal of Respiratory and Critical Care Medicine / Molecular Biology / The American Review / Journal of the American Medical Association / Journal of Immunology / The American Journal of the Medical Sciences / Critical Care Medicine / / Region New England / / Technology proteomics / apoptosis / gene expression / chemotherapy / genomics / / SocialTag 
PUTTING SYSTEMS BIOLOGY APPROACHES INTO PRACTICE ALCOHOLIC LUNG DISEASE Corey D. Kershaw, M.D., and David M. Guidot, M.D.