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Organic chemistry / Mercaptopurine / Thiopurine methyltransferase / Thiopurine / Allopurinol / Leukemia / Hepatotoxicity / Tioguanine / Chemotherapy / Medicine / Purines / Chemistry


PURINETHOL® (mercaptopurine) 50-mg Scored Tablets CAUTION PURINETHOL (mercaptopurine) is a potent drug. It should not be used unless a diagnosis of acute lymphatic leukemia has been adequately established and the respo
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Document Date: 2011-05-31 19:21:51


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City

Boston / Greenville / Washington / DC / Pittsburgh / Reference / /

Company

AMP / J Hosp Pharm / Wellcome Research Laboratories / J Health-Syst Pharm / Teva Pharmaceuticals / CBC / DSM Pharmaceuticals Inc. / /

Country

United States / Australia / /

Event

Product Issues / Product Recall / /

Facility

Massachusetts College of Pharmacy / Laboratory Tests / Mount Sinai Medical Center / Hospital Pharmacists / /

IndustryTerm

treatment of central nervous system leukemia / therapy for leukemia / /

MedicalCondition

local infection / inflammatory bowel disease / liver dysfunction / hyperpigmentation / human leukemias / parenchymal cell necrosis / leukopenia / solid tumors / nausea / thrombocytopenia / acute lymphatic leukemia / Alopecia / both intrahepatic cholestasis / Oligospermia / hepatic necrosis / thrush / decreased cellular hypersensitivities / chronic low doses / homozygous-TPMT deficiency / diarrhea / granulocytopenia / hypersensitivity / hepatosplenic T-cell lymphoma / infections / infectious agents / CA-A Cancer J / sepsis / central nervous system leukemia / sore throat / leukemia / Cancer / disease / acute leukemia / gastroenteritis / Carcinogenesis / serum hepatitis / heterozygous TPMT deficiency / neoplastic diseases / intercurrent infections / Hepatic encephalopathy / lymphomas / toxic hepatitis / fever / chronic lymphatic leukemia / Hepatic injury / Hodgkins Disease / vomiting / concomitant disease / severe depression / biliary stasis / Mild diarrhea / pre-existing liver disease / acute myelogenous leukemia / Animal tumors / anemia / /

MedicalTreatment

chemotherapy / blood transfusions / Immunosuppression / Hemodialysis / drug therapy / Dialysis / /

Organization

National Institute of Health / Dept of Health / Public Health Service / AMA Council on Scientific Affairs / PRECAUTIONS / Occupational Safety and Health Administration / Clinical Oncological Society of Australia / American Society of Hospital Pharmacists / Mount Sinai Medical Center / Clinical Center Pharmacy Department / Division of Safety / Intravenous administration / DOSAGE AND ADMINISTRATION / National Study Commission / Massachusetts College of Pharmacy and Allied Health Sciences / Clinical Practice Committee / Oncology Nursing Society / /

Person

Louis P. Jeffrey / /

Position

physician / General / responsible physician / Chairman / /

Product

trimethoprim / thioguanine / mercaptopurine / PURINETHOL / allopurinol / Scored Tablets / ZYLOPRIM / folic acid / medication / sulfamethoxazole / patients / Patients Patients / /

ProvinceOrState

Pennsylvania / North Carolina / Massachusetts / /

Technology

genotyping / Pharmacokinetics / chemotherapy / Dialysis / /

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