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Molecular biology / Applied genetics / Medical genetics / Adeno-associated virus / Viral vector / Gene therapy / Regulatory T cell / Virus / Dependovirus / Biology / T cells / Gene delivery


Office of Biotechnology Activities Office of the Director National Institutes of Health (NIH) U.S. Department of Health and Human Services Immune Responses to Adeno-Associated Virus (AAV) Vectors
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Document Date: 2013-12-10 09:43:10


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City

IFN / /

Company

Factor IX / Avigen Inc. / /

Country

Canada / Sweden / Spain / /

Currency

pence / /

Event

FDA Phase / Judicial Event / Product Issues / /

Facility

C terminus / Marina O’Reilly Dr. O’Reilly / University of Florida / /

IndustryTerm

gene transfer protocols / transportation / immunogenic transgene product / therapeutic product / product manufacturing / manufacturing process / energy / antigen-processing class / manufacturing / antigen processing / rep binding site / cryptic translation products / vector systems / cell culture systems / defective ribosomal products / terminal resolution site / possible solution / transgene product / /

MedicalCondition

HIV / viral infection / ORF / LPL deficiency / rare autosomal recessive disorder / hepatitis / tumor / AAT deficiency / cancer / focal hepatitis / inflammatory lesions / single-gene disorders / coronary artery disease / AIDS / infection / deficiency / CD8+ T-cell-mediated AAV hepatitis / Hepatocellular injury / productive infection / muscular dystrophy / liver failure / alternative ORF / hypertriglyceridemia / abdominal pain / vaccinia infection / inflammatory cytokines / human hemophilia / hemophilia B. In / cystic fibrosis / amino acid ORF / Hemophilia / AAV infection / Immune Liver Injury / biopsy hemophilia / emphysema-like disease / hemophilia B / contraction / remote infections / tumor necrosis / CD8+ T-cell-mediated liver injury / Canavan’s disease / drug-induced liver injury / liver injury / acute pancreatitis / /

MedicalTreatment

immunizations / low-fat diet / immunosuppression / booster immunization / /

Organization

Gene Transfer Safety Assessment Board / Powell Gene Therapy Center / Vectors NIH Recombinant DNA Advisory Committee / Biotechnology Activities office of the Director National Institutes of Health / NIH Recombinant DNA Advisory Committee / U.S. Department of Health and Human Services Immune Responses / University of Florida / /

Person

Leonard B. Seeff / Howard Federoff / Terence R. Flotte / Mark Brantly / Wrigh / R. Jude Samulski / Powell Gene / Hildegund C.J. Ertl / J. Fraser Wright / James M. Wilson / Nicholas Crispe / Meulenberg / Katherine A. High / Jonathan Yewdell / Nicholas Muzyczka / /

Position

low level cap messenger / Chair / /

Product

AAV-mediated / AAV-2 / ribosomal products / /

ProvinceOrState

Florida / /

Technology

apoptosis / gene expression / 856 gene transfer protocols / Recombinant DNA / Alpha / 65 protocols / cell receptors / antibodies / Biotechnology / ultrasound / Cloning / transplantation / AAV protocols / AAV protocol / 36 protocols / /

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