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ORIGINAL ARTICLE Why Most Discovered True Associations Are Inflated John P. A. Ioannidis Abstract: Newly discovered true (non-null) associations often have inflated effects compared with the true effect sizes. I discuss
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Document Date: 2014-04-02 19:45:51

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Ioannina / Boca Raton / London / Boston / Bath / /

Company

Oxford University Press / Cox / Farquhar AG / Utz HF / Melchinger AE / CRC Press / /

Country

United Kingdom / Greece / /

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Facility

University of Ioannina School / Cochrane Library / /

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clinical applications / inflexible protocols / strict protocols / comparing protocols / strict protocol / Data mining / genomic epidemiology network / possible solutions / /

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lymph-node-negative breast cancer / Alzheimer’s disease / JE / Cancer / complex diseases / Stroke / node-negative breast cancer / diabetes / J Cancer / true disease / myocardial infarction / acute stroke / heart failure / diseases / breast cancer / common diseases / /

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pharmacotherapies / /

NaturalFeature

Haahr MT / /

Organization

International Committee of Medical Journal Editors / Department of Medicine / University of Ioannina School of Medicine / Department of Hygiene and Epidemiology / Oxford University / Tufts University School of Medicine / /

Person

Duncan Thomas / Arch Intern / Reflective Replicator / Fernandez JR / John P. A. Ioannidis / Ann Intern / Van Puijenbroek / /

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Maryland / Oregon / Massachusetts / /

PublishedMedium

Lippincott Williams & Wilkins / /

Technology

alpha / DNA Chip / gene expression / Data mining / strict protocol / simulation / genotype / human genome / /

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