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Angiology / Proteins / Membrane biology / Integrin / Metastatic breast cancer / Signal transduction / Angiogenesis / Fibronectin / Disintegrin / Biology / Cell signaling / Cell biology


Anti-Cancer Agents in Medicinal Chemistry, 2010, 10, [removed]Cilengitide: The First Anti-Angiogenic
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Document Date: 2011-05-16 03:49:09

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File Size: 1,16 MB

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City

Garching / Darmstadt / Edinburgh / /

Company

Arg / Ref 13 / Macmillan Publishers Ltd. / Ligand / Bentham Science Publishers Ltd. / O N G H H HO N CO / Merck / Asp / X N CO / /

Country

Germany / /

Currency

pence / USD / /

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Event

FDA Phase / /

Facility

Horst Kessler* Institute / /

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IndustryTerm

chemical approaches / treatment of numerous diseases / chemical development / magnetic resonance imaging / cancer therapy / cancer therapies / biomedical applications / treatment of non-malignant angiogenic disorders / cancer treatment / chemical nature / narrower binding site / side chain / aqueous solution / minimal binding site / cell attachment site / metal ion-dependent adhesion site / carboxylate / chemical entity / Chemical structure / chemical strategies / /

MedicalCondition

non-malignant angiogenic disorders / glioblastoma cells / breast cancer metastasis / metastasis / solid tumors / accelerated tumor / neuroblastoma / several other tumors / gliomas / local tumor / tumor GBM / effectively prevented metastasis / non-small cell lung cancer / refractory brain tumors Pediatric brain tumors / malignant primary brain tumors / soft tissue tumor / brain tumor / brain tumors / osteolysis / glioblastoma / dissociation / autoimmune diseases / glioma response / cancer metastasis / tumor / glioblastoma xenografts / cancer / Tumors / Glanzmann thrombasthenia / liver metastasis / morphologically abnormal tumor / advanced solid tumors / glioblastomas / GBM glioblastoma / different solid tumors / refractory brain tumors / malignant glioma / SD stable disease / orthotopic brain tumors / tumor metastasis / stable disease / example tumor / inflammation / numerous diseases / metastases / breast cancer carcinoma / /

MedicalTreatment

radiation therapy / chemotherapy / radiotherapy / anti-cancer therapies / radiation / cancer therapy / drug targeting / /

Organization

pentagon / Technische Universität München / Institute for Advanced Study / Horst Kessler* Institute for Advanced Study / IMD / /

Person

Carlos Mas-Moruno / Florian Rechenmacher / /

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Position

RT / head / author / integrin head / representative / /

Product

glycine / recurrent / Single agent / Cilengitide / PFS-6 / /

Technology

radiation / X-ray / tomography / antibodies / apoptosis / MRI / pharmacokinetics / biomaterials / magnetic resonance imaging / gene expression / chemotherapy / treating cancer / spectroscopy / drug design / drug development / /

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