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City La Jolla / Los Angeles / / Company IgG / Apogee / Thermo Fisher / LG / Vector Laboratories / Reymann KG / Cummins / Millipore / Sigma-Aldrich / Amersham / Proc Natl Acad Sci U S A / Malik AB / Avelas Biosciences / MCA / GE Healthcare / Zlokovic BV / Bio-Rad / Suzuki / Microsoft / / Currency USD / / / Event Product Issues / / Facility Pike CJ / University of California San Diego / Scale bar / Hughes Medical Institute / Cedars-Sinai Medical Center / / IndustryTerm stroke prevention / stock solution / magnetic resonance imaging / imaging / vivo fluorescence imaging / statistical software / therapy for stroke / / MedicalCondition inflammatory response / unilateral cerebral hypoxia / thrombin-induced injury / JE / tissue-type plasminogen activator stroke / central nervous system injury / brain injury / endothelial injury / tissue injury / intracerebral hemorrhage / subarachnoid hemorrhage / acute stroke / injury / Introduction Stroke / neurologic deficits / myocardial ischemia/reperfusion injury / middle cerebral artery occlusion / severe neurovascular injury / Tumor / cancer / tumors / Argatroban tPA stroke / cerebral infarction / cerebral ischemia / ischemic neuronal and vascular injury / Stroke / transient focal cerebral ischemia / brain ischemia / acute focal cerebral ischemia / neurovascular injury / ischemic neurovascular injury / Focal cerebral ischemia / diseases / cellular injury / Alzheimer disease / neurodegenerative diseases / thrombus / deficiency / acute ischemic stroke / / MedicalTreatment incision / neck incision / surgery / Intravenous infusion / catheter / catheters / catheterization / / MusicGroup B.C. / / Organization National Institute of Health / Department of Defense W81XWH-05-1-0183 / Cedars-Sinai Medical Center / Institutional Animal Care and Use Committee / Department of Neurology / Image Lab / Biochemistry / and 5Howard Hughes Medical Institute / University of California San Diego / / Person Arch Neurol / Ann Neurol / Integr Biol / Bo Chen / Thrombin Chen / Ann N Y Acad Sci / / Position mediator / Author / model / Representative / endogenous mediator / mediator of neurotoxicity and memory impairment / / Product isoflurane / argatroban / thrombin / designed using argatroban / / ProvinceOrState Q.C. / British Columbia / California / / PublishedMedium The Journal of Neuroscience / / RadioStation Baik FM / Demchuk AM / Donovan FM / / Technology TUNEL staining protocol / Neuroscience / antibodies / Biotechnology / cloning / apoptosis / phage display / magnetic resonance imaging / 3g / / SocialTag 
7622 • The Journal of Neuroscience, May 30, 2012 • 32(22):7622–7631 Neurobiology of Disease Thrombin Activity Associated with Neuronal Damage during Acute Focal Ischemia