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Proteins / PRC2 / PHD finger / EZH2 / EED / Histone methylation / SET domain / Histone methyltransferase / Cellular differentiation / Biology / Genetics / Epigenetics


Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2) Chao Xua,1, Chuanbing Biana,1, Wei Yangb,1, Marek Galkac, Hui Ouyanga, Chen Chend, Wei Qiua
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City

Birmingham / Toronto / /

Company

Protein Data Bank / Wellcome Trust / Sigma Aldrich / Innovation Merck & Co. / Qiagen / GlaxoSmithKline / Jacobs SA / Novartis Research Foundation / GE Healthcare / Ontario Innovation Trust / Murzina NV / /

Country

Canada / /

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Facility

C terminus / University of Alabama / DDB1-DDB2 complex / University of Western Ontario / Mount Sinai Hospital / stable S2 / PRC2 complex / MLL1 complex / EED-EZH2 complex / dSamuel Lunenfeld Research Institute / EED-H3K27me3 complex / Samuel Lunenfeld Research Institute / N terminus / University of Toronto / Ontario Genomics Institute / College Street / H3K27me3 complex / /

IndustryTerm

reaction products / search model / large network / protein solution / reservoir solution / multi-copy search / /

Organization

Ontario Genomics Institute / Schulich School of Medicine and Dentistry / Knut and Alice Wallenberg Foundation / Samuel Lunenfeld Research Institute / Canadian Foundation for Innovation / Swedish Foundation for Strategic Research / dSamuel Lunenfeld Research Institute / Ontario Genomics Institute Genomics Publication Fund / Swedish Agency for Innovation Systems / Department of Biochemistry / University of Western Ontario / London / Ontario Ministry for Research and Innovation / University of Alabama at Birmingham / University of Toronto / Mount Sinai Hospital / /

Person

Chuanbing Biana / Farrell MacKenziea / Hengbin Wangb / Patricia Pana / Cheryl Arrowsmith / Alexey Bochkarev / Yanming Wang / Coot / Aled Edwards / Amanda E. Jonesb / Wei Yangb / Chen Chend / Site-Directed Mutagenesis Kit / Guillermo Senisterra / Shawn Shun-Cheng Lic / Marek Galkac / Chao Xua / Wei Qiua / mark may / Hui Ouyanga / /

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Position

Canada Research Chair / Model / /

ProvinceOrState

New Brunswick / Alabama / Ontario / /

Region

Western Ontario / /

Technology

alpha / X-ray / apoptosis / Functional Genomics / Structural Genomics / gene expression / Crystallization / flash / Cellular Proteomics / /

URL

www.pnas.org/cgi/doi/10.1073/pnas.1008937107 / www.pdb.org / www.pnas.org/lookup/suppl / /

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