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© 2007 Nature Publishing Group http://www.nature.com/naturebiotechnology A N A LY S I S Drug–target network Muhammed A Yıldırım1,2,3, Kwang-Il Goh1,4,5, Michael E Cusick1,2, Albert-László Barabási1,4,6 & Marc V
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Document Date: 2008-04-11 15:55:39


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Capdeville / Oxford / Mencher / Boston / Cambridge / Luscombe / Chanda / /

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A N A LY S I S a / M. & Teichmann S.A. / E. Systems / BIOTECHNOLOGY A N A LY S I S a / Target / DrugBank / Ge / Dana / /

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Korea / United States / /

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FDA Phase / Product Issues / /

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Korea University / Dana-Farber Cancer Institute / Northeastern University / National Institute of General Medical Sciences / Nieuwland Science Hall / Harvard University / University of Notre Dame / National Human Genome Research Institute / Dana Research Center / /

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chemical similarity / greater network / pharmaceutical industry / disease-gene products / Online Mendelian Inheritance / drug discovery technologies / yeast proteinprotein interaction network / The human disease network / disease networks / quantitative tools / transcriptional regulatory networks / gene products / disease-gene product / randomized drug network / distinct chemical structure / breadth-first search starting / human disease network / chemical entities / large metabolic networks / chemical entity / human protein-protein interaction network / metabolic networks / chemical screening / segregated network / collaboration networks / cellular networks / human interactome network / protein networks / regulatory networks / pharmaceutical / human transcription factor network / interactome networks / drug network / randomized gene groups / targetprotein network / random network / chemical / /

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tory disease / D. Human disease / complete known disorder / gastrointestinal and dermatological disease / common disorder / disorder / cancer / genetic disease / schizophrenia / metabolic diseases / human cancer / All disease / same disease / Distance Disease / diseases / validated disease / disorders / defective tumor / muscular and ophthalmologic disease / specific disorder / V. Dissecting human disease / same disorder / EXP Disease Essential All proteins Target proteins / mood disorders / different disease / cancers / disease / single disease / OMIM-based disorder / Metabolic disease / human disease / genetic disorders / /

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radiation therapy / /

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National Human Genome Research Institute / Northeastern University / W. M. Keck Foundation / Department of Genetics / Center for Cancer Systems Biology / Korea University / Seoul / Harvard Medical School / National Institute of Health / Harvard University / National Science Foundation / Department of Physics / National Institute of General Medical Sciences / Dana-Farber Cancer Institute / US Food and Drug Administration / University of Notre Dame / /

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Nat / Andrew L. Hopkins / William G. Kaelin / Frederick P. Roth / David E. Hill / Sheffler / /

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Butcher / D.J. / /

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Gleevec / Plenaxis / BiCNU / Largon / Zometa / Sparine / olanzapine / Reclast / Geodon / Sutent / Zyprexa / Experimental drug / one drug / tumor suppressor genes32 / /

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Mathematica / /

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Connecticut / New Mexico / S.K. / Massachusetts / /

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NATURE BIOTECHNOLOGY / /

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radiation / Anti-infectives / Human Genome / drug discovery technologies / drug discovery / DNA Chip / gene expression / Genomics / BIOTECHNOLOGY / metabolic networks / pharmacogenetics / rational drug design / drug development / /

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