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City Denver / D. Cytokine / La Jolla / / Country United States / Finland / / Event Product Issues / / Facility CD3 complex / La Jolla Institute / / IndustryTerm recent technology / / MedicalCondition autoimmune diabetes / systemic lupus erythematosus / celiac disease / congenital rubella diabetes / inflammatory gut phenotype / insulin-dependent diabetes mellitus / viral infection / A. Rare Monogenic Forms Autoimmune diabetes / accelerated diabetes / spondylitis / epidemic / rheumatoid arthritis / dysfunction / heart disease / distinct disease / autoimmune thyroid disease / juvenile-onset diabetes / multisystem disease / DIABETES A / mumps infection / chronic autoimmune disorder / childhood gastroenteritis / obesity / multiple sclerosis / enterovirus infection / selective viral infection / Enterovirus infections / autoimmune disorder / several autoimmune diseases / rotavirus infection / MS / chronic autoimmune disease / infections / both diseases / insulin gene-dosage deficiency / blindness / autoimmune diseases / beta-cell-tropic infection / insulin deficiency / insulin resistance / insulin-dependent diabetes / several other autoimmune diseases / disease / coxsackievirus infections / complex disorders / human autoimmune diseases / persistent enterovirus infection / hyperglycemia / CVB4 infection / both physical and behavioral disorders / stroke / Diabetes / Mycobacterium avium subspecies paratuberculosis / vitamin D deficiency / Diabetes Trials A. Antigen / several other prevalent autoimmune disorders / severe lymphoproliferative disorders / viral infections / kidney failure / Congenital rubella syndrome / diabetes mellitus / autoimmune disease / diseases / APECED / rubella infection / specific disease / paratuberculosis / infectious diseases / higher diabetes / certain viral infections / infection / PRECIPITATING EVENTS A. Viral Infections A / SLE / overt diabetes / autoimmune polyendocrinopathy-candidiasis / IPEX syndrome / human IDDM / congenital rubella infection / Reduce IDDM / / MedicalTreatment immunization / immunizations / antibiotics / vaccination / immunotherapy / vaccinations / / NaturalFeature Pribilof Islands / / Organization AND MATTHIAS G. VON HERRATH Center for Type / D. PTPN22 E. IL2RA F. CTLA-4 G. Genome-wide association / American Center for Disease Control / Federal Government / La Jolla Institute for Allergy and Immunology / Research Fund / American Physiological Society / HLA association / / Person TOM L. VAN BELLE / / Position physician / mouse model / the NOD mouse / mechanistic model for T1D etiology / specific driver / / Product Vitamin D / tolerance induction / Treg subset / Treg functionality / / ProvinceOrState Mississippi / California / Colorado / / Technology alpha / antibodies / transplantation / human genome / single nucleotide polymorphism / gene expression / SNP / later confirmed using PCR technology / genotype / cell assays / / URL www.prv.org / / SocialTag 
Physiol Rev 91: 79 –118, 2011; doi:[removed]physrev[removed]Type 1 Diabetes: Etiology, Immunology, and Therapeutic Strategies TOM L. VAN BELLE, KEN T. COPPIETERS, AND MATTHIAS G. VON HERRATH