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Antiretroviral drugs / Cyclopropanes / Nitriles / Pyrimidines / Reverse-transcriptase inhibitor / Nevirapine / Discovery and development of non-nucleoside reverse-transcriptase inhibitors / Etravirine / Efavirenz / Chemistry / Organic chemistry / Non-nucleoside reverse transcriptase inhibitors


doi:[removed]j.pbiomolbio[removed]
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Document Date: 2005-09-20 11:51:58


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File Size: 746,22 KB

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City

Piscataway / Vosselaar / /

Company

ARTICLE IN PRESS / Janssen Pharmaceutica NV / Elsevier Ltd. / nn co / /

Country

Belgium / United States / /

Currency

pence / USD / /

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Event

FDA Phase / Diplomatic Relations / /

Facility

Rutgers University / /

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IndustryTerm

active site / dNTP-binding site / low energy conformations / polymerase active site / chemical environment / chemical steps / Chemical structures / hydrophobic binding site / chemical compositions / chemical composition / treatment of HIV / catalytic site / chemical diversity / chemical step / chemical classes / chemical / chemical bonds / /

MedicalCondition

HIV / HIV infection / advanced HIV infection / AIDS / infection / /

MedicalTreatment

Highly active antiretroviral therapy / HAART / /

Organization

Rutgers University / Department of Chemistry and Chemical Biology / Center for Advanced Biotechnology and Medicine / United Nations / NIH National Cancer Institute / /

Person

Van Herrewege / Reverse / Van Vaerenbergh / Paul Janssen / Stephen H. Hughesc / Paul J. Lewib / Frederick / Eddy Arnolda / /

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Position

Non-nucleoside RT / RT / transcriptase ÃCorresponding author / NNRTI-resistant RT / viral enzymes RT / target enzyme RT / /

Product

Efavirenz / Samsung L100 Digital Camera / Fuzeon / Nevirapine / HIV-1 / treatmentnaı¨ / One such new drug / /

ProvinceOrState

RT / /

PublishedMedium

Molecular Biology / /

Technology

molecular modeling / X-ray / Biotechnology / polymerization / p2p / drug discovery / drug design / /

URL

www.elsevier.com/locate/pbiomolbio / /

SocialTag