Back to Results
First PageMeta Content
Biomarker / Penetrance / PCSK9 / Cystic fibrosis / Low-density lipoprotein / Rheumatoid arthritis / Genome-wide association study / Statin / Introduction to genetics / Biology / Genetics / Familial hypercholesterolemia


REVIEWS A G U I D E T O D R U G D I S C O V E RY Validating therapeutic targets through human genetics Robert M. Plenge1,2, Edward M. Scolnick2,3 and David Altshuler2,4,5
Add to Reading List

Document Date: 2013-08-24 17:52:46

Open Document

File Size: 471,59 KB

Share Result on Facebook

City

Boston / Cambridge / /

Company

Macmillan Publishers Limited. / Target / Pfizer / Vertex Pharmaceuticals / AMD / Bristol-Myers Squibb / /

Country

United States / /

Currency

AMD / USD / /

/

Event

FDA Phase / Product Issues / /

Facility

Massachusetts General Hospital / Mayo Clinic / US National Human Genome Research Institute / Brigham And Women’s Hospital / Broad Institute of MIT / /

IndustryTerm

chemical modulators / treatment of benign prostatic hyperplasia / pharmaceutical industry / animal model systems / treatment of osteoporosis / computational algorithms / Natural products / treatment of other diseases / follow-on products / gene product / bead chip / genomic technology / therapies for this disease / polarity / treatment of psoriasis / /

MedicalCondition

both disease / inflammatory bowel disease / complex disease / gain-of-function alleles Low Pulmonary / Mendelian diseases / B cell lymphoma 11A / rheumatoid arthritis / macular degeneration / given disease / heart disease / few rheumatoid arthritis / Complex traits Diseases / progeria syndrome / male pattern baldness / inflammatory cytokines / respective diseases / age-related macular degeneration / such diseases / pseudohermaphroditism / psoriasis / human diseases / Cystic fibrosis transmembrane conductance regulator / benign prostatic hyperplasia / coronary heart disease / cystic fibrosis / severe disease / coronary disease / autoimmune disease rheumatoid arthritis / sepsis / adrenal insufficiency / autoimmune diseases / Alzheimer’s disease / intermittent burning pain / hypertension / severe combined immunodeficiency / spinal muscular atrophy / disease / high phenotypic response corresponds to low disease / hypothyroidism / erythermalgia / complex diseases / mild cystic fibrosis / cardiovascular disease / diabetes / Addison’s disease / established disease / pain / active disease / myocardial infarction / pulmonary dysfunction / autoimmune disease / Drugs Disease / diseases / osteoporosis / coronary artery disease / SCID / deficiency / active rheumatoid arthritis / preclinical disease / inflammation / human disease / Marfan’s syndrome / autosomal recessive disease / /

MedicalTreatment

surgery / drug targeting / /

Organization

Harvard Medical School / Molecular Biology and Diabetes Unit / MIT / Harvard / Women’s Hospital / Massachusetts General Hospital / Broad Institute / Division of Rheumatology / Immunology and Allergy / Department of Molecular Biology / Department of Genetics and Medicine / US Food and Drug Administration / Stanley Center for Psychiatric Research / US National Human Genome Research Institute / /

Person

Gene Allele / Edward Kendall / Phillip Hench / /

Position

chemist / /

Product

finasteride / Riluzole / Orencia / hydrocortisone / lovastatin / allele / IL1 / First-in-class drug / /

ProvinceOrState

Massachusetts / /

PublishedMedium

Molecular Biology / /

Technology

alpha / antibodies / bead chip / human genome / drug discovery / gene expression / SNP / genotype / recombination / drug development / /

URL

www.nature.com/reviews/drugdisc / /

SocialTag