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THE PURINE PATH TO CHEMOTHERAPY Nobel Lecture, December 8, 1988 by GERTRUDE B. ELION Wellcome Research Laboratories, Burroughs Wellcome Co.,
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Document Date: 2006-05-31 16:51:06

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City

Boston / /

Company

B. ELION Wellcome Research Laboratories / AMP / Burroughs Wellcome Co. / Wellcome Research Laboratories / Philips / /

Currency

pence / /

Event

FDA Phase / /

Facility

SloanKettering Institute / /

IndustryTerm

treatment of acute myelocytic leukemia / condensed pyrimidine systems / biological systems / treatment of acute leukemia / diamino-pyrimidine condensed systems / treatment of autoimmune disease / immunological systems / /

MedicalCondition

AKR mouse leukemia / Chagas’ disease / Gout / severe bone marrow depression / produced severe nausea / leukemias / severe rheumatoid arthritis / adenocarcinoma / leukemia / tumor / autoimmune hemolytic anemia / chronic granulocytic leukemia / cancer / tumors / rodent tumors / acute leukemia / mouse tumors / pain / vomiting / systemic lupus / autoimmune disease / chronic active hepatitis / vaccinia virus / rash / animal tumors / acute myelocytic leukemia / /

MedicalTreatment

combination chemotherapy / kidney transplants / Chemotherapy / kidney transplantation / organ transplants / Immunosuppression / kidney transplant / /

Organization

Food and Drug Administration / SloanKettering Institute / New York Academy of Sciences / /

Person

William Dameshek / Doris Lorz / Roy Calne / Joseph Marr / Robert Schwartz / Emil Fisher / Wayne Rundles / /

Position

surgeon / /

Product

thioguanine / mercaptopurine / allopurinol / folic acid / prednisone / azathioprine / Imuran / adenosine / nitro / This compound / /

Technology

Transplantation / CHEMOTHERAPY / crystallization / /

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