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Hypoxia-inducible factors / Von Hippel–Lindau tumor suppressor / HIF1A / Hypoxia / Vascular endothelial growth factor / EP300 / DBP / Carotid body / Hydroxylation / Biology / Transcription factors / Medicine


Regulation of gene expression by HIF-1 Gregg L. Semenza, Larissa A. Shimoda* and Nanduri R. Prabhakar† Vascular Program, Institute for Cell Engineering; Departments of Pediatrics, Medicine, Oncology, and Radiation Onco
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Document Date: 2007-10-05 17:12:00

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City

HIF / Baltimore / /

Company

Novartis / EPO / Iyer NV / Cox / /

Country

United States / /

Currency

cent / Rs / CNY / /

Event

Product Issues / /

Facility

McKusick-Nathans Institute of Genetic Medicine / Case Western Reserve University / /

IndustryTerm

respiratory and circulatory systems / energy / /

MedicalCondition

chronic hypoxia manifest hypertrophy / systemic hypertension / both acute and chronic responses / hypoxia-induced pulmonary vascular remodelling / pulmonary artery smooth muscle cells / complete HIF-1a deficiency / Cardiopulmonary disorders / pulmonary vascular remodelling / pulmonary arteries / sleep-disordered breathing / Hypertension / chronic hypobaric hypoxia / Partial HIF-1a deficiency / chronic obstructive pulmonary disease / acute and chronic hypoxia Whereas / solid tumor / tumour / partial deficiency / pulmonary arterial remodelling / pulmonary hypertension / chronic hypoxia / pulmonary alveolar air sacs / pulmonary arterial myocyte electrophysiological responses / pulmonary arterioles / acute and chronic hypoxia / actually blunted following chronic hypoxia / /

NaturalFeature

Kv channel / /

OperatingSystem

OS-9 / /

Organization

Case Western Reserve University / Cleveland / National Commission on Sleep Disorders Research / Institute for Cell Engineering / Department of Physiology and Biophysics / Division of Pulmonary and Critical Care Medicine / The Johns Hopkins University School of Medicine / McKusick-Nathans Institute of Genetic Medicine / Department of Medicine / US Government Printing Office / /

Person

Joe Garcia / Charles Wiener / Larissa A. Shimoda / /

Position

General / critical mediator / /

Product

FS / LG PC12 Radio / carotid body function / physiological responses / development / /

ProvinceOrState

Ohio / Maryland / /

PublishedMedium

Critical Care Medicine / /

Technology

Radiation / ATM / apoptosis / gene expression / recombination / /

SocialTag