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Genomics / Endotoxin / Toxins / Sepsis / Human genome / Medicine / Biology / Genetics


Genomic responses in mouse models poorly mimic human inflammatory diseases Junhee Seoka,1, H. Shaw Warrenb,1, Alex G. Cuencac,1, Michael N. Mindrinosa, Henry V. Bakerc, Weihong Xua, Daniel R. Richardsd, Grace P. McDonal
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Jackson Laboratory / dIngenuity Inc. / Lash AE / Affymetrix / Pearson / /

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Natural Disaster / /

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University of Rochester School / Parkland Memorial Hospital / Stanford University / San Francisco General Hospital / National Institute / University of Pittsburgh Medical Center Presbyterian University Hospital / University of Florida College / Michael’s Hospital / Harborview Medical Center / University of Texas Medical Branch / University of Texas / Loyola University / University of California / Massachusetts General Hospital / Washington University / University of Pittsburgh / University of Colorado Anschutz Medical Campus / University of Medicine / Southwestern Medical Center / University of Toronto / University of Washington School / /

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animal model systems / animal systems / mouse model systems / injury protocols / chemicals / reagents/analytic tools / model systems / /

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Top 40 / /

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TBSA burn injury / Trauma Endotoxemia / JE / endotoxemia / severe sepsis / several other severe acute inflammatory diseases / inhalation injury / Mouse Endotoxemia / Injury / burns / human diseases / nosocomial infections / burn injury / human injuries / blunt injury / radiation injury / human in vivo endotoxemia model / different underlying acute injuries / human disease translational medicine immune response injury / Systemic Inflammatory Response Syndrome / Human Endotoxemia / Infection / human endotoxemia model / relevant human disease / several additional acute inflammatory diseases / each human disease / several additional severe acute inflammatory diseases / additional severe acute inflammatory diseases / bowel disease / MS / infections / Sepsis / human injury / Burn / disease / Discussion Studying disease / acute respiratory distress syndrome / shock / animal research reflect human disease / burn injuries / Human Trauma Human Burn Human Trauma Human Endotoxemia Mouse Burn Mouse Trauma Mouse Endotoxemia / C Human Endotoxemia Mouse Burn Mouse Trauma Mouse Endotoxemia HLA-DRA / bacterial infection / Endotoxemia S/s / infectious diseases / human inflammatory diseases / emergency department systolic hypotension / severe acute inflammatory diseases / serious injuries / syndrome / human burn injury / human disease / /

MedicalTreatment

Surgery / Immunotherapy / Plastic and Reconstructive Surgery / immunosuppression / blood transfusion / /

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C.M. / the Commission / the Council / Opal / /

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Defense Advanced Research Projects Agency / University of Texas Medical Branch / Institutional Review Board / University of Toronto / Toronto / European Parliament / Presbyterian University Hospital / Research Institute / University of Pittsburgh / European Commission / University of Colorado Anschutz Medical Campus / Denver / FDA / Harborview Medical Center / Florida College / European Union / University of California / San Francisco / Washington University / University of Medicine and Dentistry of New Jersey / Securities and Exchange Commission / Southwestern Medical Center / National Institute on Disability / University of Texas / Harvard Medical School / Stritch School of Medicine / San Francisco General Hospital / St. Michael’s Hospital / National Institute / University of Washington School of Medicine / Parkland Memorial Hospital / Massachusetts General Hospital / University of Rochester School of Medicine / Loyola University / Chicago / Stanford University / US Department of Health and Human Services Food and Drug Administration / University of Florida / Department of Surgery / Center for Drug Evaluation / /

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Marc G. Jeschkeo / Ronald G. Tompkinst / Nicole S. Gibranj / Ernest E. Mooreh / Hong Gaoa / Laura Hennessyf / Richard L. Gamellip / Ronald W. Davis / Bernard H. Brownsteinq / Ronald W. Davisa / Junhee Seoka / Lyle L. Moldawerc / Paul E. Bankeyk / Carol Miller-Grazianok / Jason Sperryl / Michael N. Mindrinosa / Avery B. Nathensm / Philip H. Masone / Ronald V. Maierj / H. Shaw Warrenb / Matthew B. Kleinj / Grace P. McDonald-Smithe / Jeffrey L. Johnsonh / W. Xu / Henry V. Bakerc / Ann Surg / Shari Honarif / David N. Herndong / Joseph P. Mineii / Celeste C. Finnertyg / Timothy R. Billiarl / Stephen F. Lowryr / Robert Wood Johnson / Alex G. Cuencac / Cecilia M. Lópezc / Steve E. Calvanor / Joseph Cuschierij / Daniel R. Richardsd / Michael A. Westn / Laurence G. Rahmet / /

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G.P. / General / Author / Major / representative / van der Worp HB / Massachusetts General / maximum Marshall / /

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radiation / injury protocols / Human Genome / gene expression / Genomics / hybridization / pdf / drug development / /

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