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Epigenetics / Transcription factors / Posttranslational modification / PCAF / CREB-binding protein / Histone deacetylase / P53 / Histone code / Acetylation / Biology / Gene expression / Proteins


A ‘molecular switchboard’—covalent modifications to proteins and their impact on transcription † Nelly Khidekel and Linda C. Hsieh-Wilson * Division of Chemistry and Chemical Engineering, California Institute of
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Document Date: 2005-08-08 21:01:58


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City

Pasadena / New York / /

Company

AMP / Matsuda / ACS / John Wiley & Sons Inc. / Q. Lu A. E. / /

Country

United States / /

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Event

FDA Phase / /

Facility

Northwestern University / CBP complex / California Institute of Technology / laboratory of Linda Hsieh-Wilson / Rockefeller University / terminus influence / University of California / Yale University / /

IndustryTerm

chemical approaches / free energy / metal ion affinity chromatography / cancer therapy / biological systems / machinery / distinct chemical modifications / multidimensional protein identification technology / molecular machinery / pre-mRNA splicing machinery / chemical functionality present / pro-apoptotic machinery / Chemical derivatization methods / invaluable tools / phosphorylation site / chemical groups / combinatorial networks / chemical repertoire / transcriptional machinery / phosphoryl / /

MedicalCondition

human cancers / neurodegenerative disorders / tumor / cancer / diseases / heat shock / /

MedicalTreatment

radiation / cancer therapy / /

Organization

California Institute of Technology / National Science Foundation / Northwestern University / University of California / Berkeley / Royal Society of Chemistry / Yale University / Rockefeller University / Division of Chemistry and Chemical Engineering / /

Person

Walter Winchell / Nat / J. E. Darnell Jr. / Linda C. Hsieh-Wilson / Nelly Khidekel / K. M. Shokat / Peter G. Schultz / H. L. Zhou / O. Buzko / Paul Greengard / A. C. Bishop / /

Position

Beckman Young Investigator / Professor / fundamental player / Bishop / /

Product

cisplatin / deferoxamine mesylate / CP31398 / Ser5 / /

ProvinceOrState

New York / California / /

PublishedMedium

Molecular Biology / /

Technology

radiation / Proteomics / antibodies / multidimensional protein identification technology / DNA binding / human genome / apoptosis / gene expression / treating cancer / condensation / /

URL

http /

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