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Mammalian target of rapamycin / Signal transduction / Sirolimus / Glutamate dehydrogenase / SIRT4 / Sirtuin / Tuberous sclerosis / Glutaminolysis / Insulin-like growth factor 1 / Biology / Chemistry / Biochemistry


The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4 Alfred Csibi,1 Sarah-Maria Fendt,2,6 Chenggang Li,3,5 George Poulogiannis,4,5 Andrew Y. Choo,1 Douglas J. Chapski,1 Seung Min
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Document Date: 2013-05-10 11:41:23


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File Size: 1,54 MB

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City

Boston / Leuven / Cambridge / /

Company

IgG / Elsevier Inc. / ADP / Dura / Intracellular KG / /

Country

United States / /

Currency

AOA / /

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Event

Product Recall / Product Issues / /

Facility

Flemish Institute of Biotechnology / Beth Israel Medical Center / Women’s Hospital / Massachusetts Institute of Technology / /

IndustryTerm

energy-addicted cancers / media lacking pyruvate / biosynthetic machinery / putative bTrCP-binding site / energy / energy production / tumor systems / energy maintenance / phosphorylation site / cellular energy / low-energy conditions / gas chromatography/mass spectrometry / /

MarketIndex

set 195 / /

MedicalCondition

metastasis / several tumor / carcinoma / both ELT3 xenograft tumors / energy-addicted cancers / Pulmonary / mouse Tsc2+/ liver tumors / TSC2-expressing tumors / MS / breast cancer / prostate cancer DU145 / cancers / tumor / colon carcinoma DLD1 / cancer / human epithelial tumor / tumors / human cancer / carcinomas / leiomyoma cell line ELT3 expressing / tumor suppressors tuberous sclerosis / /

Organization

Harvard Medical School / Flemish Institute of Biotechnology / Vesalius Research Center / Women’s Hospital / Massachusetts Institute of Technology / Department of Medicine / NS NS / Department of Systems Biology / African Union / Beth Israel Medical Center / Department of Medicine / Brigham and Women / /

Person

Alfred Csibi / /

Position

SIRT4 messenger / pGL3 luciferase reporter / representative / reporter / /

Product

GFs / /

ProvinceOrState

Massachusetts / /

PublishedMedium

Critical Care Medicine / /

Technology

computer algorithm / electrophoresis / siRNA / antibodies / Biotechnology / gas chromatography / 3G / /

URL

http /

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